Is ethnicity linked to the severity of SLE manifestations?

Nature Reviews Rheumatology, Published online: 15 July 2019; doi:10.1038/s41584-019-0271-1Epidemiological data on the prevalence and severity of specific manifestations of systemic lupus erythematosus (SLE) among different ethnic groups are now emerging. The use of rigorous epidemiological methods should enable a better understanding of these features of SLE in different ethnic groups, which could influence disease management.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research

Related Links:

Publication date: Available online 16 August 2019Source: Veterinary MicrobiologyAuthor(s): Wang Bi, Xiao-Long WangAbstractParvovirus disease is a highly contagious infectious disease in dogs, which is often accompanied by acute hemorrhagic enteritis and other symptoms, and leads to changes in the faecal microbial flora. To explore these changes in the fecal microbial flora in infected dogs, we used real-time PCR to detect the viral copy numbers in dogs diagnosed with the disease, and measured their blood indices, blood coagulation time, serum calcium, phosphorus, and other biochemical indices. We also determined the specie...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
CONCLUSION: Thrombophilias are inherited or acquired predispositions to vascular thrombosis and have been associated with thrombosis of the arteriovenous fistula. Patients on hemodialysis with recurrent vascular access thrombosis and presence of thrombophilia should be evaluated about the need for anticoagulant therapy with a vitamin K antagonist. PMID: 31419276 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Authors: Wang P, Mao YM, Liu LN, Zhao CN, Li XM, Pan HF Abstract A growing body of data suggests that semaphorins are involved in both normal and pathological immune responses, as well as autoimmune pathologies. To investigate the plasma semaphorin 3A (Sema3A) and semaphorin 7A (Sema7A) levels in systemic lupus erythematosus (SLE) patients and their correlation with clinical manifestations and laboratory indexes, a two-step method was applied. First, 80 SLE patients and 80 healthy controls were recruited for comparing serum Sema3A and Sema7A concentrations. Second, 40 rheumatoid arthritis (RA) patients and 40 sj&ou...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Prestigious Carol Nachman Prize for Research in Rheumatology Awarded to Ellen Gravallese On May 10, Ellen M. Gravallese, MD, the Myles J. McDonough Chair in Rheumatology and chief of the Division of Rheumatology at University of Massachusetts Medical School, Worcester, was awarded the prestigious Carol Nachman Prize for lifetime achievement in rheumatology research in Wiesbaden,... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Awards Profiles Carol Nachman Prize Dr. Alfred H.J. Kim Dr. Alysia Kwiatkowski Dr. Ellen M. Gravallese Lupus Leadership Award Source Type: research
Toll-like receptors play an important role in host defense. TLR-7 recognizes viral ssRNA, but also plays a role in the development of systemic lupus erythematosus (SLE). Genetic ablation of a similar receptor, TLR-9, results in opposite effects, with severe disease and kidney involvement. The mechanism of how this works remains unknown. Anna-Marie Fairhurst, PhD, from... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews SLE (Lupus) mouse model TLR-7 TLR-9 TLRs Toll-like receptors Source Type: research
ConclusionThis study provides evidence that hsa_circRNA_001264, hsa_circRNA_104121, and hsa_circRNA_045355 might be biomarkers for pSS, correlate with pSS etiology.Key Points•Many circRNAs were dysregulated in pSS patients.•Differentially expressed circRNAs correlated with pSS clinical, laboratory features.•CircRNAs may be biomarkers for pSS.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 14 August 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): D. Gururaja, Veeraj HegdeAbstractSystemic Lupus erythematosus is the classic prototype of multisystem disease of autoimmune origin. SLE may be associated Vasculitis as an overlap syndrome. In this paper, a patient diagnosed as SLE with Vasculitis, which was managed successfully by Ayurveda treatment was discussed. A 39-year-old female patient came to hospital with complaint of severe pain and burning sensation in both the legs for two months, associated with ulceration and gangrene of toes of both the legs for th...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Condition:   Systemic Lupus Erythematosus (SLE) Interventions:   Drug: AMG 570;   Drug: Placebo for AMG 570 Sponsor:   Amgen Not yet recruiting
Source: - Category: Research Source Type: clinical trials
We report a case of a 41-year old female with systemic lupus erythematosus and Sjögren's syndrome, who developed symptoms of painful small fiber neuropathy (SFN). Examination using in vivo confocal microscopy (IVCM) revealed dense accumulations of putative dendritic cells in the central cornea that was postulated to represent a peripheral neuro-inflammatory response. Interventions with higher dose prednisolone, and then intravenous immunoglobulin resulted in substantial, progressive improvements in her symptoms, which were paralleled by cumulative reductions in corneal dendritic cell density (DCD). This case identifie...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutritional assessment II Source Type: research
More News: Epidemiology | Lupus | Rheumatology