Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Spatially fractionated radiotherapy was developed and reported in 1909 by Alban K öhler, a German radiologist, to reduce extensive damage to skin and adjacent tissues when he irradiated deep seated tumours with low voltage (60–70 kV) X-rays. To this effect, he held a shielding iron wire grid tightly against the skin before exposure. The heavily irradiated, necrotic spots of the unshielded skin healed in few weeks. Variants of grid therapy were then used successfully in clinical external beam radiotherapy since the 1930s [1].

Source: Radiotherapy and Oncology - July 11, 2019 Category: Radiology Authors: Laura Eling, Audrey Bouchet, Christian Nemoz, Valentin Djonov, Jacques Balosso, Jean Laissue, Elke Br äuer-Krisch, Jean Francois Adam, Raphael Serduc Tags: Original Article Source Type: research