Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
It is not clear how regulation of T-cell function is altered during development of inflammatory bowel diseases (IBD). We studied the mechanisms by which geranylgeranyltransferase-mediated prenylation controls T-cell localization to the intestine and chronic inflammation.
Source: Gastroenterology - Category: Gastroenterology Authors: Roc ío López-Posadas, Petra Fastancz, Luz del Carmen Martínez-Sánchez, Julia Panteleev-Ivlev, Veronika Thonn, Tatyana Kisseleva, Lukas S. Becker, Anja Schulz-Kuhnt, Sebastian Zundler, Stefan Wirtz, Raja Atreya, Birgitta Carlé, Oliver Friedrich, Sebas Source Type: research
More News: Gastroenterology | Inflammatory Bowel Disease