Comparing Within- and Between-Family Polygenic Score Prediction

Polygenic scores are a popular tool for prediction of complex traits. However, prediction estimates in samples of unrelated participants can include effects of population stratification, assortative mating, and environmentally mediated parental genetic effects, a form of genotype-environment correlation (rGE). Comparing genome-wide polygenic score (GPS) predictions in unrelated individuals with predictions between siblings in a within-family design is a powerful approach to identify these different sources of prediction.

Source: The American Journal of Human Genetics - July 10, 2019 Category: Genetics & Stem Cells Authors: Saskia Selzam, Stuart J. Ritchie, Jean-Baptiste Pingault, Chandra A. Reynolds, Paul F. O ’Reilly, Robert Plomin Tags: Article Source Type: research