Is It Possible That IV Immunoglobulin Does Not Improve Outcome in Children With Guillain-Barré Syndrome? Answer: Yes*
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Abstract Plasma exchange is a highly efficient technique to remove circulating autoantibodies and other humoral factors rapidly from the vascular compartment. It was the first effective acute treatment for peripheral disorders such as Guillain-Barré syndrome and myasthenia gravis before intravenous immunoglobulin became available. The recent recognition of rapidly progressive severe antibody-mediated central nervous system disorders, such as neuromyelitis optica spectrum disorders and anti-N-methyl-D-aspartate-receptor encephalitis, has renewed interest in using plasma exchange for their acute treatment als...
Recurrent Guillain-Barré Syndrome with Anti-GT1a and Anti-GQ1b Ganglioside Antibodies. J Clin Neurol. 2019 Jul;15(3):404-406 Authors: Hwang J, Kwon YJ, Kim JK, Kim NJ, Baek SH PMID: 31286716 [PubMed]
This case documents stress cardiomyopathy as a potentially lethal complication of Guillain-Barre syndrome, highlighting the need for early diagnosis.Journal of Medical Case Reports
Morgan Williams, 23, was living in Kona, Hawaii, when she fell ill with the flu in March 2018 before she was paralyzed from the waist down. She was soon diagnosed with Guillain-Barré syndrome.
Jean-Charles Chatelin (1884-1948), counted among the "Righteous", but forgotten as a neurologist who studied under Pierre Marie. Rev Neurol (Paris). 2019 Jul 03;: Authors: Walusinski O Abstract Charles Chatelin (1884-1948) studied under Pierre Marie (1853-1940) at hôpital La Salpêtrière and went on to a career profoundly affected by World War I. He wrote a remarkable thesis on the clinical aspects and radiography of hereditary craniofacial dysostosis, which had been recently described by Octave Crouzon (1874-1938). A few days after the publication of Georges Guillain (1876-...
Conclusion: Guillain-Barre syndrome is commonly seen in the young population. The most common symptom of Guillain-Barre syndrome was ascending paralysis. The in-hospital mortality rate of patients with GBS was 6.45%. PMID: 31275647 [PubMed]
We describe a 40-year-old woman who presented with lower cranial neuropathies mimicking variant Guillain-Barré syndrome, with normal brain and spinal cord imaging and cerebrospinal fluid (CSF) albuminocytological dissociation, and subsequently diagnosed with IgD myeloma. She relapsed repeatedly with differing neurological presentations: numb chin syndrome and twice with impaired vision, first from cerebral venous sinus thrombosis and later from leptomeningeal infiltration of the optic chiasm. We discuss the neurological complications of myeloma, emphasising the need to consider it in a wide variety of neurological p...
A woman with a history of Guillain-Barre syndrome presents for care. What vaccines would you give her?Medscape Internal Medicine
Conclusion: AMAN is still the most common subtype of GBS in northern China. A decline in dCMAP amplitude is predictive factor of a slow recovery and poor outcome of GBS. Diarrhea and CBs may be the factors for better short-term prognosis in AMAN patients in Northern China.
Conclusions: In Indian children with Guillain-Barré syndrome, the outcome at 6 months in IV immunoglobulin treated group was similar to non-IV immunoglobulin group. Children with acute motor axonal neuropathy responded better to IV immunoglobulin.