The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats.

The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats.
Biotech Histochem. 2019 Jul 04;:1-8
Authors: Baltaci AK, Gokbudak H, Baltaci SB, Mogulkoc R, Avunduk MC
Abstract
We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.
PMID: 31271315 [PubMed - as supplied by publisher]

Source: Biotechnic and Histochemistry - July 3, 2019 Category: Research Authors: Baltaci AK, Gokbudak H, Baltaci SB, Mogulkoc R, Avunduk MC Tags: Biotech Histochem Source Type: research