4 ′-Guanidinium-modified siRNA: A molecular tool to control RNAi activity through RISC priming and selective antisense strand loading

This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ganesh N. Nawale, Saeed Bahadorikhalili, Pallabi Sengupta, Sandeep Kadekar, Subhrangsu Chatterjee, Oommen P. Varghese We designed novel 4 ′-C-guanidinocarbohydrazidomethyl-5-methyl uridine (GMU) modified small interfering RNA (siRNA) and evaluated their biophysical and biochemical properties. Incorporation of GMU units significantly increased thermodynamic stability as well as the... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chem. Commun. latest articles - July 5, 2019 Category: Chemistry Authors: Ganesh N. Nawale Source Type: research