Baicalein protects normal human epidermal keratinocytes against bullous pemphigoid immunoglobulin G-induced alteration

In the skin, hemidesmosome connects basal keratinocytes to the basement membrane, and two major hemidesmosome proteins, BPAg2/collagen XVII (BP180) and BPAG1/dystonin (BP230), play a pivotal role in adhering basal keratinocytes to the basement membrane [1 –5]. BP230 is associated with intracellular hemidesmosomal plaques and BP180 links basal keratinocytes to the basement membrane [1]. Bullous pemphigoid (BP) is a common autoimmune bullous dermatosis in elderly population, characterized by large and tense blisters.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research