Effect of a Residual Biofilm on Release of Transforming Growth Factor β1 from Dentin

Several studies have reported regeneration of the pulp-dentin complex when treating noninfected root canal systems. However, current protocols applied to infected root canal systems are much less predictable for the formation of dentin. Converging lines of evidence implicate residual biofilm as an important factor for these variable histologic outcomes. Here we studied the effect of a residual polymicrobial biofilm on the release of transforming growth factor beta 1 (TGF- β1) from dentin. We hypothesized that the presence of bacterial biofilm attenuates the release of bioactive molecules from dentin.

Source: Journal of Endodontics - July 1, 2019 Category: Dentistry Authors: Ritter Cameron, Espitia Claudia, Wu Ping, Son Erin, Nikita B. Ruparel Tags: Regenerative Endodontics Source Type: research