37-Year-Old Man With Fatigue and Erectile Dysfunction

A 37-year-old man presented to the primary care clinic with fatigue, subjective muscle weakness, erectile dysfunction, and decreased libido of several months' duration. These symptoms had progressively worsened over several months. He also reported poor morning erections, decreased motivation, loss of interest in activities he previously found enjoyable, depression, anxiety, sleep disturbance, and snoring. He reported no weight changes, headaches, or vision changes. His medical history was notable for generalized anxiety, gastroesophageal reflux disease, and long-standing obesity.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents' clinic Source Type: research

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Authors: Koller G, Schwarzer A, Halfter K, Soyka M Abstract Introduction: Opioid addiction is a worldwide disease with a significant impact. A multitude of physical and mental comorbidities are associated with opioid addiction, pain being one of the most relevant. Insufficient pain management may lead to a disruption in medical treatment, self-medication, and subsequent harm to patients. Areas covered: In this review, the authors provide a general overview of opioid addiction. A literature search for pain management and opioid maintenance treatment was conducted. Different settings of acute or chronic pain and situ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 16 August 2019Source: Aggression and Violent BehaviorAuthor(s): Gregory M. Vecchi, Gilbert K.H. Wong, Paul W.C. Wong, Mary Ann MarkeyAbstractLaw enforcement agencies often deal with dangerous, difficult, and disordered individuals by applying the theory and practice of tactical negotiation composed of a unique application of communication techniques aimed at obtaining voluntary compliance. Known as hostage or crisis negotiation, law enforcement tactical negotiation (LETN) has shown to be an effective technique for resolving barricaded hostage and crisis situations, kidnappings, and suicid...
Source: Aggression and Violent Behavior - Category: Psychiatry & Psychology Source Type: research
Hi guys, I've been dealing with a lot lately, trying to get myself calmed down before college starts back up in a week (Senior I). I may take a few days just to compose myself before sprinting into worrying about yet another standardized test (which have been an nemesis of mine in the past). I'm having severe pre-mcat anxiety. I don't even know where to begin. My general chemistry courses and microbiology course will be this semester, which ends in December. My genetics and... The MCAT: Where TF do I start?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: MCAT: Medical College Admissions Test Source Type: forums
Publication date: Available online 16 August 2019Source: Brain StimulationAuthor(s): Debra J. Stultz, Savanna Osburn, Tyler Burns, Robin Walton, Sylvia Pawlowska Wajswol
Source: Brain Stimulation - Category: Neurology Source Type: research
We examined several parameters including reproductive performance of dams, physical development, postnatal reflex ontogeny, locomotor behavior, neuromuscular strength, anxiety, anhedonic behavior, cognitive abilities and microglia populations in the F1 progeny. The study showed improved reproductive performance of Spirulina supplemented protein malnourished dams, accelerated acquisition of neurological reflexes, better physical appearance, enhanced neuromuscular strength, improved spatial learning and memory and partly normalized PMN induced hyperactivity, anxiolytic and anhedonic behavior in offspring. These beneficial ef...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 16 August 2019Source: The LancetAuthor(s): Michel D Ferrari, Hans Christoph Diener, Xiaoping Ning, Maja Galic, Joshua M Cohen, Ronghua Yang, Matthias Mueller, Andrew H Ahn, Yael Carmeli Schwartz, Melissa Grozinski-Wolff, Lindsay Janka, Messoud AshinaSummaryBackgroundAntibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have shown efficacy in the prevention of migraine attacks. We investigated the efficacy and tolerability of fremanezumab, a fully humanised CGRP antibody, in patients with migraine who had previously not responded to two to four classes of migraine pre...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 16 August 2019Source: The LancetAuthor(s): Alessandro Tessitore, Antonio Russo
Source: The Lancet - Category: General Medicine Source Type: research
The objective of this study was to develop virtual environments that include elements that are culturally relevant to the population of the Dominican Republic. Three hundred people with symptoms of agoraphobia were interviewed. Based on the information obtained, four scenarios were designed: house, elevator, park and public transport. In each scenario, the parameters that increase anxiety levels (for example, number of people) may be controlled and modified, allowing the development of exposure levels.
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Publication date: Available online 16 August 2019Source: International Journal of PharmaceuticsAuthor(s): Pavan Kumar Nukala, Siddhant Palekar, Manali Patki, Yige Fu, Ketan PatelAbstractLoperamide, an over the counter anti-diarrheal drug, also infamously referred to as “poor man's methadone”. Due to the ease of availability and low price, people/patients abuse it by consuming more than 30 tablets to achieve euphoric effect and to combat opioid withdrawal. But supratherapeutic doses of loperamide result in severe respiratory depression, cardiac dysrhythmia and mortality. To address this issue, we developed ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
In conclusion, most drugs are more effective than placebo, and there are few significant differences between the active drugs and placebo on acceptability. Overall, duloxetine and escitalopram showed better efficacy while vortioxetine showed better acceptability.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
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