Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis

Publication date: Available online 26 June 2019Source: The LancetAuthor(s): Mélanie Drolet, Élodie Bénard, Norma Pérez, Marc Brisson, Hammad Ali, Marie-Claude Boily, Vincenzo Baldo, Paul Brassard, Julia M L Brotherton, Denton Callander, Marta Checchi, Eric P F Chow, Silvia Cocchio, Tina Dalianis, Shelley L Deeks, Christian Dehlendorff, Basil Donovan, Christopher K Fairley, Elaine W Flagg, Julia W GarganoSummaryBackgroundMore than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human papillomavirus on HPV infections, anogenital wart diagnoses, and cervical intraepithelial neoplasia grade 2+ (CIN2+) to summarise the most recent evidence about the effectiveness of HPV vaccines in real-world settings and to quantify the impact of multiple age-cohort vaccination.MethodsIn this updated systematic review and meta-analysis, we used the same search strategy as in our previous paper. We searched MEDLINE and Embase for studies published between Feb 1, 2014, and Oct 11, 2018. Studies were eligible if they compared the frequency (prevalence or incidence) of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed CIN2+) between pre-vaccination and post-vaccination periods among the general population and if they used the same population sources and recruitment methods before and a...
Source: The Lancet - Category: General Medicine Source Type: research