Primary Cutaneous Anaplastic Large-Cell Lymphoma

A 35-year-old male presented with a 6-month history of asymptomatic, generalised, self-healing lesions. On clinical examination, there were diffuse, ulcerated, necrotic papules and nodules with lymphoedema of the face. Histology sections confirmed atypical lymphoid-type cells which appeared round-to-oval with irregular nuclei (horseshoe-shaped). Immunohistochemistry stains were positive for CD30, CD3, and epithelial membrane antigen. The features were in keeping with an anaplastic large-cell lymphoma, T cell type. This transformed into a systemic variant of the disease after the patient had completed chemotherapy.Dermatopathology 2019;6:163 –169
Source: Dermatopathology - Category: Pathology Source Type: research

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Conclusions Liposuction can safely be performed with lymph node transfer in 1 operation to achieve optimal results in patients with chronic lymphedema. The combined technique provides immediate volume reduction and further regenerative effects on the lymphatic circulation. The significantly greater reduction in lymphoscintigraphy values and erysipelas infections suggests that the combined technique might be better for late-stage lymphedema patients than lymph node transfer alone.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Microsurgery Source Type: research
We report a case of primary cutaneous diffuse large B-cell lymphoma, leg type, associated with chronic lymphedema of the lower limbs. A literature review identified 12 additional cases of primary cutaneous lymphomas associated with chronic lymphedema. Chronic lymphatic stasis may cause a local dysfunction of the immune system that predisposes to the induction of neoplasia, cutaneous lymphomas in particular. PMID: 31361244 [PubMed - in process]
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Tags: Indian J Pathol Microbiol Source Type: research
Conclusion: Presence of chylous ascites suggests severe disease in children with PIL. Majority of PIL children respond to dietary therapy; only 20% need additional therapy. Long-term follow-up is essential to monitor for symptoms relapse and complications.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous subtype of non-Hodgkin ’s lymphoma characterized by a cutaneous infiltration of malignant T lymphocytes. Treatment may include local irradiation of the skin lesions using external beam radiation therapy (EBRT) or High Dose Rate (HDR) brachytherapy. Lesions located on extremities can be difficult to treat with EBRT, part icularly when they wrap around the limb, due to the curvature of the surface and the associated risk of lymphedema. We propose a technique for HDR brachytherapy that is adequately suited for such challenging targets.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Summary: Lymphaticovenous anastomosis (LVA) is primarily performed for lymphedema of the lower extremities after surgical treatment of gynecologic cancer and lymphedema of the upper extremities after surgical resection of breast cancer; however, LVA for lymphedema due to malignant lymphoma has not been reported to date. We herein present a patient with severe lymphedema of the lower extremities due to refractory malignant lymphoma, which markedly improved with LVA. LVA could contribute to improve quality of life in patients with end-stage disease with lymphedema of the lower extremities due to refractory malignant lymphoma.
Source: Plastic and Reconstructive Surgery – Global Open - Category: Cosmetic Surgery Tags: Case Report Source Type: research
Abstract Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B cell lymphoma. T cell malignancy has rarely been associated with chronic lymph stasis. Here we report a case of primary cutaneous anaplastic large cell lymphoma (pcALCL) with lymphatic spread associated with chronic lymphedema. The patient is a 56‐year‐old man who received orchiectomy and right inguinal lymphadenectomy for malignant seminoma 10 years ago, which led to prominent lymphedema of the right leg. He developed extensive skin nodules on the lymphedematous area for 3 months. Histopatholog...
Source: Journal of Cutaneous Pathology - Category: Pathology Authors: Tags: CASE REPORT Source Type: research
This article is protected by copyright. All rights reserved. PMID: 27377879 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Research Letter Source Type: research
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Research Letter Source Type: research
ConclusionPatients with secondary leg lymphedema can benefit from LNFT. Results in patients with mild presentations seem to be better than in more severe cases. © 2015 Wiley Periodicals, Inc. Microsurgery, 2015.
Source: Microsurgery - Category: Surgery Authors: Tags: Clinical Article Source Type: research
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