Perfusion MRI at rest in subacute and chronic myocardial infarct.

Perfusion MRI at rest in subacute and chronic myocardial infarct. Acta Radiol. 2013 Feb 11; Authors: Hopp E, Bjørnerud A, Lunde K, Solheim S, Aakhus S, Arnesen H, Forfang K, Edvardsen T, Smith HJ Abstract BackgroundPerfusion magnetic resonance imaging (MRI) and delayed contrast-enhanced MRI (DE-MRI) serve as tools for tissue characterization.PurposeTo assess and compare semi-quantitative parameters of myocardial infarct (MI) in the subacute and chronic phase, and to correlate these parameters with qualitative enhancement analysis.Material and MethodsPerfusion MRI at rest and DE-MRI were performed in 63 patients with anterior wall MI at 2-3 weeks after revascularization and repeated after 6 months. Descriptive enhancement parameters of contrast arrival time, initial upslope, enhancement at normal tissue peak (TTP(n)) and wash-out slope, and kinetic tissue parameters rBF, K(trans), k(ep) and v(e) were calculated. Subacute infarct tissue was compared to normal myocardium and chronic infarct tissue. Patients were stratified at baseline according to a qualitative grading of hypoenhancement based on first-pass enhancement and presence of microvascular obstruction (MO) at perfusion MRI and on persistent MO at DE-MRI. The qualitative grade was correlated to semi-quantitative perfusion MRI parameters.ResultsInitial upslope, enhancement at TTPn, rBF, and k(ep) were decreased and wash-out slope and v(e) were increased in infarct tissue (P
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Source: La Radiologia Medica - Category: Radiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Magnetic Resonance Materials in Physics, Biology and Medicine - Category: Materials Science Source Type: research
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Source: Magma - Category: Radiology Authors: Tags: MAGMA Source Type: research
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Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
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Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
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Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
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Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Conditions:   Kidney;   Perfusion Imaging;   Ultrasonography Interventions:   Diagnostic Test: Contrast enhanced ultrasound;   Diagnostic Test: Arterial Spin Labelling -Magnetic Resonance Imaging Sponsor:   University of Nottingham Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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