A Review on Parenteral Delivery of Peptides and Proteins.

A Review on Parenteral Delivery of Peptides and Proteins. Drug Dev Ind Pharm. 2019 Jun 19;:1-33 Authors: Jain D, Mahammad S, Singh PP, Kodipyaka R Abstract The recent advances in pharmaceutical industry in the area of drug delivery and development have resulted into wide variety of biomolecules, particularly peptides and proteins, to palliate the treatment for severe diseases. The rampant development of peptides and proteins in industry mandate the understanding of their characteristic nature and developability. Despite their therapeutic potential, peptides and proteins pose complex challenges in drug delivery and require scientist to contemplate to achieve suitable delivery system. As most of the commercial products for proteins and peptides are available as a parenteral delivery and Freeze drying process is one commonly used technique, it is imperative to understand the complex steps of development for better and faster product development. This review provides an overview of the stability and formulation development for peptides and proteins. The most common route for protein delivery, parenteral, has been focused with parenteral solution and lyophilisation as formulation strategy. Additionally, new drug delivery, formulation, and half-life extension approaches will further the reach of this unique class of molecules. Efforts are underway to explore the area with new technologies and development. PMID: 31215293 [PubMed - a...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research