Outcomes of Intraoperative Radiotherapy for Early-Stage Breast Cancer: Experience from a Multidisciplinary Breast Oncology Program

ConclusionsIORT is a safe and effective alternative to whole breast radiotherapy, and serves as a suitable alternative to completion mastectomy in locally recurrent breast cancer.Summary for the table of contentsA multidisciplinary breast cancer center experience of intraoperative radiation therapy (IORT) in early stage breast cancer patients. Single high dose IORT was implemented in lieu of prolonged daily whole breast radiation as part of breast conserving therapy. IORT was found to be safe and effective alternative to WBRT in select early stage breast cancer patients.
Source: The American Journal of Surgery - Category: Surgery Source Type: research

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Post Mastectomy Radiation Treatment (PMRT) is an important component of the multidisciplinary management of local advanced breast cancer patients. Hypofractionation has become the new standard of care after breast conserving surgery but has not been yet adopted in the setting of post mastectomy radiation (PMRT) in most countries.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Authors: Omranipour R Abstract Surgery in the form of both mastectomy and breast conservation is the main step in the treatment of breast cancer. Numerous studies have shown an equivalent long-term survival for breast conserving surgery (BCS) and mastectomy . Patients desire and tumor characteristics, especially size and multicentricity, are the key factors that affect the decision between these two types of surgery . Patients with any contraindication for radiotherapy or previous history of radiation to the breast field are not suitable for BCS . There are few absolute contraindications for BCS , and early pr...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionsPatient preference is difficult to define and measure, and heterogeneity across studies renders direct comparison difficult. Future work is needed to define women ’s risk-thresholds for certain treatments, delve into the psychological factors that direct their decisions, and understand how patients’ valuations of risk interact with society’s.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Clinical trials support adjuvant regional nodal irradiation (RNI) after breast conserving surgery (BCS) or mastectomy for patients with lymph node-positive breast cancer. Advanced treatment planning techniques (e.g., intensity-modulated radiation therapy [IMRT]) may reduce dose to organs-at-risk (OARs) in this situation. Yet, uncertainty persists about when IMRT is clinically indicated (versus 3D conformal radiation, 3DCRT) for RNI. We hypothesized that an adaptive treatment planning algorithm (adaptive-TPA) for IMRT adoption would allow OAR constraints for RNI to be met when 3DCRT could not without significantly changing ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Several decades ago, the concept of deintensification of breast cancer treatment began with randomized trials demonstrating breast conservation therapy (BCT) was equivalent to mastectomy with respect to recurrence and survival and optimized functional outcomes and quality of life. Radiation therapy (RT) has remained a mainstay of BCT, traditionally defined as lumpectomy followed by adjuvant RT and hormone therapy (in estrogen receptor –positive patients). The rationale for incorporating adjuvant radiation is the ability to eliminate microscopic disease after lumpectomy that could otherwise manifest as a local recurre...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Conditions:   Anatomic Stage I Breast Cancer AJCC v8;   Anatomic Stage IA Breast Cancer AJCC v8;   Anatomic Stage IB Breast Cancer AJCC v8;   Anatomic Stage II Breast Cancer AJCC v8;   Anatomic Stage IIA Breast Cancer AJCC v8;   Anatomic Stage IIB Breast Cancer AJCC v8 ;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJC...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: OS did not differ between the 2 groups in early breast cancer patients with 1 or 2 metastatic axillary lymph nodes who underwent TM. Omission of ALND may be considered in selected patients. PMID: 32528907 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Abstract PURPOSE: To develop recommendations for management of patients with breast cancer (BC) with germline mutations in BC susceptibility genes. METHODS: The American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology convened an Expert Panel to develop recommendations based on a systematic review of the literature and a formal consensus process. RESULTS: Fifty-eight articles met eligibility criteria and formed the evidentiary basis for the local therapy recommendations; six randomized controlled trials of systemic therapy met eligibility criteria. ...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
Conclusion: Breast-conserving surgery and radiation therapy prove to be an appropriate treatment option for breast cancer patients in terms of overall survival and disease-free survival when indicated. PMID: 32181017 [PubMed - in process]
Source: International Journal of Surgical Oncology - Category: Surgery Tags: Int J Surg Oncol Source Type: research
CONCLUSION: Substantial deviation from the SG for post-operative RT was observed after PST, especially in patients with an intermediate-risk. Future analyses will evaluate outcome of these patients in relation to risk factors and the actual RT given. PMID: 32058873 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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