Lipoxygenase and α -Glucosidase Inhibitory Constituents of Phlomis stewartii

Two new sphingolipids, stewartins A: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyoctadec-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-D-glucopyranoside,1] and B: [(2S,3S,4R)-2-{[(2R,11E)-2-hydroxyeicos-11-enoyl]amino}tetraeicosane-1,3,4-triol-1-O-β-glucopyranoside,2], along with nine known compounds (3 –11) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant ofPhlomis stewartii. Compounds1,2,4, and6 showed inhibitory potential against the enzyme lipoxygenase (LOX) in a concentration-dependent manner with IC50 values ranging between 42.2 ± 0.2 to 55.7 ± 0.8 μM, whereas compounds3,5, and7 –11 showed inhibition against enzyme the α-glucosidase with IC50 values between 201.4 ± 0.6 to 277.7 ± 0.3 μM, respectively.

Source: Chemistry of Natural Compounds - June 18, 2019 Category: Chemistry Source Type: research