Hypertrophic and keloid scars fail to progress from the CD34-/ α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression.

CONCLUSIONS: Both abnormal scar types (Hscar and Kscar) showed a unique CD34-/α-SMA+/p16+ scar phenotype, but the differences between Hscar and Kscar observed in this study were of a gradient rather than absolute nature. This suggests that scar progression to the mature normal scar phenotype is, for as yet unknown reasons, hindered in hypertrophic and keloid scars. This article is protected by copyright. All rights reserved. PMID: 31206605 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31206605?dopt=Abstract

Source: The British Journal of Dermatology - June 16, 2019 Category: Dermatology Authors: Limandjaja GC, Belien JM, Scheper RJ, Niessen FB, Gibbs S Tags: Br J Dermatol Source Type: research