Hypertrophic and keloid scars fail to progress from the CD34-/ α-SMA+ immature scar phenotype and show gradient differences in α-SMA and P16 expression.

CONCLUSIONS: Both abnormal scar types (Hscar and Kscar) showed a unique CD34-/α-SMA+/p16+ scar phenotype, but the differences between Hscar and Kscar observed in this study were of a gradient rather than absolute nature. This suggests that scar progression to the mature normal scar phenotype is, for as yet unknown reasons, hindered in hypertrophic and keloid scars. This article is protected by copyright. All rights reserved. PMID: 31206605 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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In this study, the authors demonstrate that intralesional 5-fluorouracil injection after keloid excision prevents recurrence for 2 years, with no reported adverse events. The authors analyze the expression of treated and untreated biopsy specimens of the same keloids in their native context to capture insights that may be missed by in vitro cell culture models and correct for intrakeloid variability. Random forest analysis of the microarray data dramatically increased the statistical power of the authors’ results, permitting hypothesis-free creation of a gene expression profile of 5-fluorouracil–treated keloids...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Experimental: Ideas and Innovations Source Type: research
Conclusion Galectin-7 may participate in the pathogenesis of hypertrophic scars and keloids through controlling both epidermal keratinocytes and dermal fibroblasts. It could be a potential therapeutic target for the management of such scars.
Source: Journal of the Egyptian Womenís Dermatologic Society - Category: Dermatology Tags: Original articles Source Type: research
SUMMARY As the celiac disease (CD), the non-celiac gluten sensitivity (NCGS) has also been associated with several autoimmune manifestations. It is rarely associated with myasthenia gravis (MG). This paper shall introduce the case of a young female patient, initially presenting a peripheral neuropathy framework. During clinical and neurological follow-up, she began to present symptoms of various immune-mediated morbidities. Diseases related to gluten represent a clinical spectrum of manifestations with a trigger in common, the ingestion of gluten. CD is the most well-known and serious disease of the spectrum, also called g...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Contributors : Alexandros Onoufriadis ; Chao-Kai Hsu ; Chrysanthi Ainali ; Chuin Y Ung ; Ellie Rashidghamat ; Hsing-San Yang ; Hsin-Yu Huang ; Umar Niazi ; Jui-Chu Yang ; Rosamond Nuamah ; Alka Saxena ; Emanuele de Rinaldis ; John A McGrathSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructKeloids represent a common form of exaggerated wound scarring that cause considerable morbidity. Moreover, there are limited data on molecular mechanisms underlying keloids and effective therapies are lacking. To gain new insight in the transcriptomic alterations of wound healing in keloid-prone i...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Contributors : Alexandros Onoufriadis ; Chao K Hsu ; Chrysanthi Ainali ; Chuin Y Ung ; Ellie Rashidghamat ; Hsing-San Yang ; Hsin-Yu Huang ; Umar Niazi ; Jui-Chu Yang ; Rosamond Nuamah ; Alka Saxena ; Emanuele de Rinaldis ; John A McGrathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeloids represent a common form of exaggerated wound scarring that cause considerable morbidity. Moreover, there are limited data on molecular mechanisms underlying keloids and effective therapies are lacking. To gain new insight in the transcriptomic alterations of wound healing in keloid-prone individu...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
‚ÄčA patient presented to the emergency department with a request to remove her back ring. Yes, that's right, her back ring. We were a bit confused at first by the piercing. The stud was placed in her back with no obvious way of removal. Our original thought was to send the patient to dermatology or even plastic surgery. The piercing certainly didn't qualify for emergency surgery or removal.‚Äč‚Äč‚ÄčA 23-year-old woman with a back piercing in the left lower back. The underlying skin condition is not infectious. This is a classic example of tinea versicolor, and is not related to the piercing. It is a common fungal infectio...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
In this study, a case of toe keloid after nail extraction is presented, in which the keloids on both toes were resected by surgical excision. Keloids (from the Greek word meaning “crab's claw”) are fibrous growths that extend beyond the original area of injury to involve the adjacent normal skin. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas, such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful.Patient concerns:A 20-year-old Chinese man had paronychia on both halluxes when he was 16 years old. He ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 28 October 2017 Source:Burns Author(s): Peter D. Drummond, Linda F. Dawson, Fiona M. Wood, Mark W. Fear Stimulation of α1-adrenoceptors evokes inflammatory cytokine production, boosts neurogenic inflammation and pain, and influences cellular migration and proliferation. Hence, these receptors may play a role both in normal and abnormal wound healing. To investigate this, the distribution of α1-adrenoceptors in skin biopsies of burn scars (N=17), keloid scars (N=12) and unscarred skin (N=17) was assessed using immunohistochemistry. Staining intensity was greater on vascular sm...
Source: Burns - Category: Dermatology Source Type: research
We report an interesting and rare case of primary umbilical endometriosis mistaken for a keloid and review the literatures. PMID: 28966521 [PubMed]
Source: Annals of Dermatology - Category: Dermatology Tags: Ann Dermatol Source Type: research
ConclusionsTwo dermoscopic features, salmon‚Äźcolored area/background and serpentine vessels, are frequently seen in PCBCL lesions. These characteristic dermoscopic features, although not specific, can suggest a possible diagnosis of PCBCL.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Short Report Source Type: research
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