Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes and Adverse Events.

CONCLUSION: Systemic RV is difficult to treat effectively. Complete remission of RV was achieved in 62% and partial response in 38% of patients within 12 months of rituximab use. Further evidence is needed to inform treatment for patients with RV. PMID: 31203225 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research

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We present a case of a patient that experienced severe hemorrhagic occlusive retinal vasculitis secondary to injection of 1.0 mg/0.1 ml of intracameral vancomycin for endophthalmitis prophylaxis after an uneventful cataract surgery. The case is especially unique in that our patient ended up maintaining 20/25 vision with an ocular disease that is typically visually threatening. This may be due to the aggressive administration of periocular and oral steroids combined with scheduled anti-VEGF injections that were later transitioned into a treat and extend regimen. PMID: 31418634 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: December 2018Source: Best Practice &Research Clinical Rheumatology, Volume 32, Issue 6Author(s): Jonathan TL. Cheah, John J. Faragon, Kristen M. MarksAbstractHepatitis B and C viruses present dual considerations in rheumatic disease as both etiologic factors and important comorbidities that must be assessed and addressed. This review summarizes the link between hepatitis B and arthritis and polyarteritis nodosa as well as hepatitis C and arthritis, Sicca syndrome and cryoglobulinemic vasculitis. Recent data pertaining to the antiviral management in these conditions, especially regarding the use of the...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Central neuropathic pain can be difficult to treat and, subsequently, cause a great amount of disability and distress to patients, which limits quality of life. Common etiologies include the following: stroke, spinal cord injury, multiple sclerosis, infection, vasculitis, and malignancy. This case is a description of an 18-yr-old male patient diagnosed with a grade IV diffuse glioma who experienced severe neuropathic pain refractory to first-line treatment options including the following: gabapentinoids, tricyclic antidepressants, and selective serotonin and norepinephrine reuptake inhibitors. The patient remained on high-...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Case Report Source Type: research
Conclusions: The findings of the present study suggest that the phenotypic characteristics of EOM closely resemble those of otitis media associated with EGPA in early stages before the appearance of vasculitis. Therefore, it is challenging to differentiate the two conditions purely on the basis of otorhinological examinations.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
The objectives of this review are to outline results of the main recent therapeutic studies for SNV, which have led to establishment of current treatment strategies and significant improvement in patients' outcomes, and to describe knowledge gaps that current research hopes to bridge. Expert opinion: Therapy is mainly dictated by diagnosis, disease extent, and severity. In ANCA-associated vasculitis, an initial induction phase consists of tapering glucocorticoids combined with specific immunosuppressants. Maintenance therapy begins after 3 to 6 months, once all evidence of active disease has resolved, and can require years...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Conclusion: This case report describes the unusual case of a postoperative bacterial endophthalmitis presenting with characteristic signs of HORV, a largely untreatable, exceedingly rare phenomena that commonly results in poor visual acuity. PMID: 31414916 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
In an international clinical trial, adding the drug belimumab to standard maintenance therapy for patients in remission with vasculitis did not lower the relapse rate. The double-blind, placebo-controlled study evaluated the safety and efficacy of belimumab as adjunctive therapy to maintain remission in anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Results of the multi-center, industry-sponsored... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews Vasculitis ANCA-Associated Vasculitis anti-neutrophil cytoplasmic antibodies (ANCA) belimumab relapse Remission Source Type: research
Conclusion: We discuss here how the PDGFa, CARD11, LFNG, GPER1 and MAFK genes, included in the deletion 7p22, could be involved in the clinical and biological features of the two patients.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article discusses important clinical and imaging findings used to distinguish these disorders.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
Publication date: Available online 14 August 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): D. Gururaja, Veeraj HegdeAbstractSystemic Lupus erythematosus is the classic prototype of multisystem disease of autoimmune origin. SLE may be associated Vasculitis as an overlap syndrome. In this paper, a patient diagnosed as SLE with Vasculitis, which was managed successfully by Ayurveda treatment was discussed. A 39-year-old female patient came to hospital with complaint of severe pain and burning sensation in both the legs for two months, associated with ulceration and gangrene of toes of both the legs for th...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
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