Generation of an integration-free human induced pluripotent stem cell line MUSIi010-A from occipital scalp fibroblasts of a male patient with androgenetic alopecia

Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of pluripotent markers and by in vitro trilineage differentiation. The MUSIi010-A line was shown to retain normal karyotype and free of SeV vectors at passage 17. This iPSC line can be used for studying pathological mechanisms of AGA.
Source: Stem Cell Research - Category: Stem Cells Source Type: research

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Conditions:   Alopecia Areata;   Alopecia Totalis;   Alopecia Universalis Intervention:   Combination Product: Stem Cell Educator therapy combined with minoxidil Sponsors:   Tianhe Stem Cell Biotechnologies Inc.;   Yale University;   Hackensack Meridian Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: FN had an interesting biological effect on stem cell induction. These findings support the use of this drug for hair loss control and the development of regeneration approaches.
Source: In Vivo - Category: Research Authors: Tags: Experimental Studies Source Type: research
SummaryHair loss is a common dermatosis symptom and side-effect in cancer chemotherapeutics. Imiquimod application at mid and late telogen activated the hair follicle stem cells leading to premature hair cycle entry. Based on quinoline structure, a newly synthesized compound 6b displayed proliferation activity in vitro and in vivo through branch chain replacement and triazole ring cyclization. Toll-like receptors (TLRs) are also critical mediators of the immune system, and their activation is linked to various diseases. The present study aimed to expand new agonists within co-crystallization of TLR7 (PDB code: 5GMH); howev...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Title: Can Stem Cells Be the Cure for Baldness?Category: Health NewsCreated: 7/1/2019 12:00:00 AMLast Editorial Review: 7/2/2019 12:00:00 AM
Source: MedicineNet Skin General - Category: Dermatology Source Type: news
A potential cure for baldness using human stem cells was presented at the International Society for Stem Cell Research (ISSCR) conference on Thursday in Los Angeles.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, 45 patients were assessed using the marginal TA severity scoring system, and their biopsies (both longitudinal and transverse sections) were systematically assessed by three dermatopathologists, the aim being to correlate histopathological findings with clinical staging. Intraclass correlation coefficients were used to determine the level of agreement between the assessors. We found poor agreement of the identification and grading of perifollicular and interfollicular fibrosis (0.55 [0.23 –0.75] and 0.01 [2.20–0.41], respectively), and no correlation could be drawn with the clinical severity scor...
Source: Dermatopathology - Category: Pathology Source Type: research
Ritika Arora, Sagrika ShuklaInternational Journal of Trichology 2019 11(3):128-131 Hair loss or alopecia in males is very common, and so is its treatment. Until now, platelet-rich plasma has been in use for hair regeneration, which has shown results but lacks regenerative potential as compared to platelet-rich fibrin (PRF). Injectable-PRF (i-PRF) is advanced version of PRF in liquid form which can be injected and contains stem cells with high regenerative potential. Hair regeneration in Type VI and Type VII was observed which are difficult to treat. Hair growth with i-PRF has better regenerative potential. All cases repor...
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
UCLA researchers have discovered a new way to activate the stem cells in hair follicles that are responsible for hair growth.Research led by three UCLA faculty members —Heather Christofk, an associate professor of biological chemistry;William Lowry, a professor of molecular, cellular and developmental biology; andMichael Jung, a distinguished professor of chemistry and biochemistry — led to the discovery of compounds that, in research in mice, enabled hair follicle stem cells to promote lactate production and, consequently, hair growth.The compounds and the technology have been exclusively licensed by UCLA to P...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
AbstractAzole antifungals are first-line options in the prophylaxis and treatment of invasive fungal infections. They are often used for prolonged (weeks to months) periods of time, particularly in patients with hematologic malignancies, or in those who have received a solid organ or hematopoietic stem cell transplant. Long-term use of azoles is associated with hepatotoxicity and hormone-related effects, including gynecomastia, alopecia, decreased libido, oligospermia, azoospermia, impotence, hypokalemia, hyponatremia, and (rarely) adrenal insufficiency. Voriconazole and posaconazole have been associated with peripheral ne...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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