High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms

Modern Pathology, Published online: 12 June 2019; doi:10.1038/s41379-019-0284-yHigh frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms
Source: Modern Pathology - Category: Pathology Authors: Source Type: research

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Authors: Salchow DJ Abstract Orbital disorders in childhood include various pathologies. Whereas neoplastic lesions and structural anomalies (which frequently cause strabismus) predominate in newborns and infants, vascular lesions become more common in toddlers. Inflammatory lesions are less common than in adults and affect mostly older children and adolescents. The most common orbital mass in infants and young children is a dermoid cyst, a benign lesion.Rhabdomyosarcoma as the most common primary orbital malignancy and neuroblastoma as a common metastasis to the orbit should be considered in children with new onse...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
In this study, we characterize and differentiate the ultrasound (US) findings of deep infantile hemangioma (DIH) and venous malformation (VM).MethodsA total of 135 patients (140 lesions) with clinically proven DIH and VM were analyzed. The following US characteristics were assessed: size, shape, border, echogenicity, echotexture, vascularity, and lesion softness. One-way analysis of variance, nonparametric test, χ2 test, Fisher exact test, and paired sample t-test were used to analyze the US results.ResultsOn gray-scale US images, DIH and VM were more common in subcutaneous soft tissue, but VM could invade the muscle. ...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
Proliferating infantile hemangioma promotes α-fetoprotein production by HepG2 cells. Pediatr Res. 2019 Aug 14;: Authors: van Schaijik B, de Jongh J, Marsh RW, Munro M, Itinteang T, Tan ST PMID: 31412353 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
We described the effectiveness of surgical and radiation therapy in a case of recurrent hemangioma in the thoracic spine with extraosseous extension causing progressive paraparesis. We retrospectively reviewed a case of vertebral recurrent hemangioma treated by posterior spinal decompression and fusion and subsequent radiation therapy.A 61-year-old woman suffered from neurological deficits caused by a hemangioma in the thoracic spine. Despite initial treatment by posterior decompression, subtotal transpedicular tumor resection, and posterior spinal fusion, her neurological symptoms due to tumor compression recurred 5 yea...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
ConclusionUncommon imaging evolutions of focal liver lesions in cirrhosis may represent a challenge for the abdominal radiologist, with atypical changes in size, and internal vascularization changes that may lead to misdiagnoses.
Source: Abdominal Imaging - Category: Radiology Source Type: research
Authors: Ikeda S, Kobayashi T, Saito M, Komatsuda A, Ubukawa K, Kameoka Y, Takahashi N Abstract A 72-year-old man presented with a 6-month history of systemic edema. Hyperpigmentation, hemangioma, pleural effusion, IgG-kappa-type monoclonal protein, high vascular endothelial growth factor (VEGF) values, renal failure, and nerve conduction study abnormalities were also present. Multiparameter flow cytometry (MFC) showed 0.2% neoplastic plasma cells (CD38-, CD56-, and kappa-positive; CD19-, CD27-, and lambda-negative) in the bone marrow leading to POEMS syndrome. Cases involving kappa-type POEMS syndrome are extremel...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Purpose of review Sturge–Weber syndrome (SWS) is a rare, congenital disease which frequently involves the eye. It is important that ophthalmologists recognize this syndrome and are aware of its range of ocular manifestations. The aim of this article is to present our understanding of the pathogenesis and clinical manifestations of this syndrome and provide updated information on the treatment of SWS glaucoma and choroidal hemangioma. Recent findings SWS glaucoma usually fails medical management. Surgical options include angle procedures, filtering procedures, device placement, and combination procedures. Combina...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: PEDIATRICS AND STRABISMUS: Edited by Cynthia Alley Source Type: research
Purpose of review To evaluate the medical literature on the use of β-blockers, through different routes, for the treatment of periorbital infantile hemangiomas and to summarize the recommendations available on dosage and monitoring. Recent findings β-blockers for the treatment of infantile hemangioma are now considered to be first-line treatment. Growing literature on the role of oral propranolol confirmed its efficacy but also presented its multiple side-effects including hypotension, bradycardia, hypoglycemia, and bronchospasm. No universal guidelines exist concerning pretreatment evaluation, dosage, monit...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: PEDIATRICS AND STRABISMUS: Edited by Cynthia Alley Source Type: research
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Source: British Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Immunologic adverse reactions of β-blockers and the skin. Exp Ther Med. 2019 Aug;18(2):955-959 Authors: Tatu AL, Elisei AM, Chioncel V, Miulescu M, Nwabudike LC Abstract β-Blockers are a widely utilised class of medication. They have been in use for a variety of systemic disorders including hypertension, heart failure and intention tremors. Their use in dermatology has garnered growing interest with the discovery of their therapeutic effects in the treatment of haemangiomas, their potential positive effects in wound healing, Kaposi sarcoma, melanoma and pyogenic granuloma, and, more recently,...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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