A Call for Hope-Centered Work: A Preliminary Study of Oncology Social Workers ’ Perceptions of the Role and Value of Hope at End-of-Life

AbstractThis paper examines the role and value of hope in the experiences of people with cancer at end-of-life according to the social workers who counsel them. Despite discussion of hope ’s value in social work literature, it continues to be de-emphasized in end-of-life (EOL) social work training and discourse in favor of theories of grief, loss and bereavement. In an online survey, social workers affiliated with a national oncology social work organization (n = 67) responded to closed-ended items. They assessed personal views on and experiences of hope, views on hope within the context of EOL and work experiences with EOL patients, felt competency in assessment of and engagement with hopefulness/hopelessness, and related training and support. Several open-ended items we re also included and provided supplemental qualitative data. Participants recognized the value of hope hypothetically. However, their responses showed disagreement about the value of hope when it was considered within the context of EOL. They felt comfortable engaging in hope-centered discussion wit h EOL patients, yet did not routinely assess or encourage exploration of hope or hopelessness. There is a need for qualitative research to further explore social workers’ understanding of hope at EOL and therapeutic engagement related to it.
Source: Clinical Social Work Journal - Category: Psychiatry & Psychology Source Type: research

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Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
Abstract V-domain Ig suppressor of T-cell activation (VISTA), which belongs to the B7 family and is expressed predominantly on hematopoetic cells, myeloid, granulocytic and T cells, can suppresses T-cell activation in vivo and vitro. The blockade of VISTA has displayed brilliant results in certain murine tumor models. But to date, little is known about the expression and impact of VISTA in human cervical cancer (CC). To fill this gap of information, we systemically investigated the expression of VISTA on tumor cells, intratumoral immune cells (ICs) and vascular endothelial cells (VECs) in a group of patients with ...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
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Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
The objective of the present work was to isolate and chemically characterize the active compounds of the methanolic extract of the roots of I. sonorae and to evaluate their antiproliferative activity and induction of apoptosis. By chromatographic column separation and using NMR spectroscopy experiments, cucurbitacin IIb (CIIb), known as 23,24-dihydrocucurbitacin F or hemslecin B, was isolated and identified for the first time as a chemical constituent of the crude methanolic extract of this plant. The antiproliferative activity of CIIb was evaluated by MTT assay, and the apoptosis induction capacity was monitored by annexi...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
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Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Conclusion: In conjunction with the high levels of DJ-1 expression in osteosarcoma tissues and cell lines, the present results suggested that RA exhibited anticancer effects in osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway. Therefore, DJ-1 might be a biological target for RA in osteosarcoma cells.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Conclusions: ATL-1 acts as an effective agent to suppress colorectal tumor progression, mainly by inhibiting CRC cell proliferation through altering apoptosis, glucose metabolism, and stem-like behavior. These processes were mediated by the AKT/mTOR signaling pathway both in vitro and in vivo. ATL-1 may be a potential agent to be used in molecular-targeted strategies for cancer treatment.G A
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Authors: Law S, Leung AW, Xu C Abstract Celastrol is used in traditional Chinese medicine for treating cancers. However, its low water solubility and poor tumour selection represent major pitfalls for clinical application. In the present study, gold nanoparticle (AuNP) firstly was conjugated with PVP-co-2-dimethylaminoethyl methacrylate (Polymer) and celastrol then modified by folic acid. The as-prepared folate receptor-targeted celastrol AuNP (FCA) was characterized using attenuated total reflection Fourier transform infrared spectroscopy, UV-Vis spectrometry, transmission electron microscope, and inductively coup...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
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