AR variants: lost in translation to clinical practice?

Nature Reviews Urology, Published online: 10 June 2019; doi:10.1038/s41585-019-0204-4The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging development of clinical decision-making tools involving ARVs.

Source: Nature Reviews Urology - June 9, 2019 Category: Urology & Nephrology Authors: Florian Handle Frank Claessens Source Type: research