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Prostatectomy vs Radiotherapy: 15-Year Functional Outcomes Are the Same

Fifteen years after treatment for localized prostate cancer, men who underwent radical prostatectomy reported no differences in urinary, bowel, or sexual function compared with men who underwent external-beam...
Source: OncologySTAT Latest News - Category: Cancer & Oncology Source Type: news

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This study evaluated the outcome with a treatment strategy for high-risk prostate cancer (PCa) using extended pelvic lymph-node dissection (eLND) followed by external beam radiation therapy (EBRT) in lymph-node-positive (LNpos) and lymph-node-negative (LNneg) cases compared with the strategy with limited pelvic lymph-node dissection (lLND) and only giving EBRT to LNneg cases. MATERIALS AND METHODS: From 2000 to 2006, 124 men with high-risk PCa underwent lLND and initiated androgen deprivation therapy (ADT) before planned EBRT. LNpos patients were excluded from EBRT following the SPCG-7 study strategy (group I). From 20...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusions In high-risk renal-cell carcinoma after nephrectomy, sunitinib has been considered as treatment choice. In localized prostate cancer, prostate-cancer-specific mortality was low irrespective of the treatment assigned (active monitoring, radical prostatectomy and external-beam radiotherapy). In metastatic castration-resistant prostate cancer new results of treatment with enzalutamide and abiraterone has been published, which have been shown beneficial effects in metastatic and no metastatic patients.
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
In a cohort of 1898 patients treated with a uniform external-beam radiation therapy treatment approach for prostate cancer, prostate-specific antigen (PSA) fluctuations were carefully evaluated to determine their impact on long-term survival outcomes. Multivariate analysis demonstrated that the occurrence of a PSA bounce in the follow-up period predicted for reduced PSA recurrences, decreased incidence of distant metastases, and improved cause-specific and overall survival outcomes.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Abstract: Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent 18F-fluorocholine PET/CT prior to treatment with 223Ra-dichloride to reveal additional active lesions in the prostate gland and lymph nodes. Subsequent scans performed at the midpoint and end of 223Ra-dichloride therapy showed resolution of this soft tissue activity alongside declining bone lesion activity. Concomitant increases in plasma interleukin 6 were detected, suggesting that immune system activation may have mediated the soft tissue response. Abscopal effects usually encountered with external beam radiothera...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Conclusions Despite delivery of higher doses, men treated with contemporary IMRT reported fewer gastrointestinal, and possibly fewer sexual side effects than men treated with EBRT in the mid-1990s. However, delivery of dose-escalated IMRT may cause more urinary side effects.
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
Abstract In MR only radiation therapy planning, generation of the tissue specific HU map directly from the MRI may improve radiation therapy planning. The aim of the work is to generate and validate substitute CT (sCT) scans generated from standard T2 weighted MR pelvic scans in prostate radiation therapy dose planning. A Siemens Skyra 3T MRI scanner with laser bridge, flat couch and pelvic coil mounts was used to scan 39 patients scheduled for external beam radiation therapy for localized prostate cancer. For sCT generation a whole pelvis MRI was acquired. Patients received a routine planning CT scan. Co-register...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
Conclusion: The interpretation of 68Ga-PSMA-11 PET/CT for prostate cancer staging is highly consistent among observers with high levels of experience, especially for nodal and bone assessments. Initial training on at least 30 patient cases is recommended to ensure acceptable performance.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
Abstract IntroductionTo evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer (PCa). MethodsWe included men with localized PCa treated with three‐dimensional conformal radiotherapy (3D‐CRT) or intensity‐modulated radiation therapy (IMRT) of escalated dose (≥74 Gy in 1.8 or 2 Gy fractions) between 1992 and 2013 at an NCI‐designated cancer centre. Men receiving androgen deprivation therapy were excluded. The non‐treatment day ratio (NTDR) was defined as the number of non‐treatment days divided by the total elapsed days of therapy. NTDR was ...
Source: Australasian Radiology - Category: Radiology Authors: Tags: Radiation Oncology —Original Article Source Type: research
CONCLUSIONS: High-risk prostate cancer treated with permanent prostate brachytherapy and supplemental external beam radiotherapy resulted in excellent long-term biochemical control and PCSM. Overall, PCSM was low in all cohorts but highest in the intermediate PSA group (10.1-20 ng/ml). PMID: 28951747 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conditions:   Prostate Cancer;   Head and Neck Cancer Interventions:   Radiation: External beam radiotherapy for prostate cancer;   Radiation: External beam radiotherapy for head and neck cancer Sponsor:   Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cancer | Cancer & Oncology | External Beam Therapy | Prostate Cancer