P- role of glucocorticoid receptor in glomerular disease.

P- role of glucocorticoid receptor in glomerular disease.
Am J Physiol Renal Physiol. 2019 Jun 05;:
Authors: Goodwin JE
Abstract
Glucocorticoids are potent anti-inflammatory agents that are commonly used in the treatment of various glomerular diseases. Data from in vitro and in vivo studies, in both animals and humans, convincingly demonstrate that glucocorticoids have many beneficial direct effects on glomeruli, including podocytes, suggesting that, in theory, systemic administration is not necessary to achieve therapeutic benefit. Indeed, it is increasingly recognized that systemic steroids often have an unfavorable risk-benefit ratio. As we move into an age of personalized medicine, strategies to develop targeted steroid delivery systems and individualized risk assessment algorithms are desirable in clinicians' efforts to 'first, do no harm.'
PMID: 31166704 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - June 4, 2019 Category: Physiology Authors: Goodwin JE Tags: Am J Physiol Renal Physiol Source Type: research