Sensing of cell death by myeloid C-type lectin receptors.

Sensing of cell death by myeloid C-type lectin receptors.
Curr Opin Immunol. 2013 Jan 16;
Authors: Sancho D, Reis E Sousa C
Abstract
Molecules associated with dead or dying cells can be detected by receptors on macrophages and dendritic cells. Signals from these receptors impact myeloid cell function and play a role in determining whether death is silent or proinflammatory, tolerogenic or immunogenic. Prominent among myeloid receptors detecting dead cells are C-type lectin receptors (CLRs). Signals from these receptors variably induce endocytosis of cell corpses, corpse degradation, retrieval of dead cell-associated antigens and/or modulation of immune responses. The sensing of tissue damage by myeloid CLRs complements detection of pathogens in immunity and represents an ancient response aimed at restoring tissue homeostasis.
PMID: 23332826 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - January 16, 2013 Category: Allergy & Immunology Authors: Sancho D, Reis E Sousa C Tags: Curr Opin Immunol Source Type: research