Genetic variation in the ABCB1 gene associated with post treatment lyme disease syndrome status
Publication date: Available online 30 May 2019Source: Meta GeneAuthor(s): Joanna Lyon, Hyunuk SeungAbstractPost Treatment Lyme Disease Syndrome (PTLDS) poses a difficult to understand health issue. This multi-centered, randomized control trial studied the possible correlation between ABCB1 (MDR1) gene variants and the incidence of PTLDS in affected patients. Genomic DNA was isolated and analyzed for four ABCB1 gene SNPs (rs1128503, rs1045642, rs2235067, and rs4148740). Significant findings include the association of rs1128503 TC variant with PTLDS status. Additionally, the rs1128503+ rs1045642+ rs2235067 SNP combination increased rs1128503 genotype TC significance to 3.83 times the rs1128503 genotype CC. The TT variant of rs4148740 in conjunction with rs1128503 reduced the odds ratio and appeared to convey a PTLDS protective status to the rs1128503 TC variant.
Title: What Happens if You Go Untreated for Lyme Disease?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/29/2020 12:00:00 AM
Authors: Franco-Avecilla D, Yeung C, Baranchuk A PMID: 32575061 [PubMed - in process]
Authors: Semproni M, Rusk R, Wuerz T PMID: 32575059 [PubMed - in process]
LYME disease is a bacterial infection that can be spread to humans by infected ticks, tiny spider-like creatures that dwell in woodland. Untreated Lyme disease can cause a host of debilitating health problems so it is vital to act on the early warning sign.
Compared to the standard two-tiered testing (STTT) algorithm for Lyme disease serology using an enzyme immunoassay (EIA) followed by Western blotting, data from the United States suggest that a modified two-tiered testing (MTTT) algorithm employing two EIAs has improved sensitivity to detect early localized Borrelia burgdorferi infections without compromising specificity. From 2011 to 2014, in the Canadian province of Nova Scotia, where Lyme disease is hyperendemic, sera submitted for Lyme disease testing were subjected to a whole-cell EIA, followed by C6 EIA and subsequently IgM and/or IgG immunoblots on sera with EIA-pos...
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia ...
Authors: Slater S Abstract The value of publishing case reports has long been debated and the arguments are summarised. Last year, to encourage trainees, the Royal College of Physicians of Edinburgh's Senior Fellows Club inaugurated an annual prize for the best case report or case series published in the Journal of the Royal College of Physicians of Edinburgh by a doctor in training. Some of the highlights of last year's entries are reviewed, commented on and developed. They include cases of myelofibrosis and cherubism due to secondary hyperparathyroidism from renal failure; reversible blindness in diabetic ketoaci...
The coronavirus testing debacle, much like early Lyme testing, is a reminder that diagnostics aren't perfect.Undark
Lyme borreliosis is the most prevalent tick-borne disease in the northern hemisphere.1 Over the last decades, marked increases in the incidence of Lyme borreliosis have been reported in several Western European countries and the United States (US), with substantial impact on public health.2 –6 Erythema migrans is the most common early skin manifestation of the disease, and responds well to antibiotic treatment.7 However, erythema migrans is often not observed preceding disseminated Lyme borreliosis manifestations such as neuroborreliosis, Lyme arthritis and Lyme carditis.
Tick-borne diseases like Lyme are on the rise in the US, but a survey has found that programmes to assess and control tick populations are lacking