CM01: a facility for cryo-electron microscopy at the European Synchrotron

Recent improvements in direct electron detectors, microscope technology and software provided the stimulus for a `quantum leap' in the application of cryo-electron microscopy in structural biology, and many national and international centres have since been created in order to exploit this. Here, a new facility for cryo-electron microscopy focused on single-particle reconstruction of biological macromolecules that has been commissioned at the European Synchrotron Radiation Facility (ESRF) is presented. The facility is operated by a consortium of institutes co-located on the European Photon and Neutron Campus and is managed in a similar fashion to a synchrotron X-ray beamline. It has been open to the ESRF structural biology user community since November 2017 and will remain open during the 2019 ESRF – EBS shutdown.

Source: Acta Crystallographica Section D - May 27, 2019 Category: Biochemistry Authors: Kandiah, E. Giraud, T. de Maria Antolinos, A. Dobias, F. Effantin, G. Flot, D. Hons, M. Schoehn, G. Susini, J. Svensson, O. Leonard, G.A. Mueller-Dieckmann, C. Tags: cryo-TEM ESRF PSB cryo-EM platform CM01 feature articles Source Type: research