Gene expression in blood from an individual with β‐thalassemia: An RNA sequence analysis

ConclusionWe compare our findings with published results of RNA ‐sequencing analysis of sickle cell disease and erythroblasts from a KLF1‐null neonate with hydrops fetalis, and recognize similarities and differences in their transcriptional expression patterns.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Publication date: Available online 5 August 2020Source: Microvascular ResearchAuthor(s): Ian P. Blakely, Renita E. Horton
Source: Microvascular Research - Category: Biochemistry Source Type: research
This article provides a review of pulmonary hypertension in majority countries, focusing in detail on the most common causes in these regions, and highlights contextual challenges faced. Recent findings Epidemiological data confirms a complex and overlapping array of causes, with pulmonary hypertension because of conditions such as rheumatic heart disease, HIV, schistosomiasis, chronic lung disease and sickle cell disease. Delayed pulmonary hypertension diagnosis remains a concern and is ascribed to a lack of resources and lack of pulmonary hypertension awareness by health professionals. Pulmonary hypertension diagnosis...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Steven D. Nathan and Christopher S. King Source Type: research
Conclusions: Behavioral impacts are highly prevalent in children with SCD. Individuals in socioeconomic classes C2 and D suffered more behavioral impacts than individuals in classes B2 and C1.RESUMO Objetivo: Avaliar aspectos sociodemogr áficos e clínicos de crianças com doença falciforme (DF) e suas características comportamentais. Métodos: Aplicação de entrevista sobre aspectos socioeconômicos e outras condições de saúde e do questionário de capacidades e dificuldades (SDQ) em pais de pacientes de quatro a dez anos com DF, em um amb...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
Conclusions: Among individuals with SCD who endorse substance use, there was markedly more stress and distress with higher rates of depression and poorer quality of life. Interventions focusing on improving distress tolerance and coping to not only pain, but also social stressors, might reduce substance use. PMID: 32762425 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
AbstractSleep disturbance is common among children with sickle cell disease (SCD) and is related to neurocognitive difficulties. However, research on sleep disturbances and related variables among adults with SCD is extremely limited. The present study examined the relationship between sleep, executive functioning, and emotional functioning among 62 adults (29 females;M age  = 32 years, SD = 7.79) with SCD preparing to undergo a stem cell transplant. Participants were administered a neurocognitive evaluation that included objective and subjective measures of executive functioning, and they complete...
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractIntroducing newborn screening (NBS) services for sickle cell disease (SCD) in Africa has been proven to be one of the most cost-effective approach to reducing morbidity and mortality associated with this condition. In view of this evidence, efforts have been made by countries in Africa where SCD prevalence is high to pilot NBS programmes and to strengthen comprehensive care services for SCD. While it is important to reap the benefits of NBS for SCD in Africa in terms of overall quantitative measures, it is also important to understand how certain social and cultural conditions may disproportionately influence the o...
Source: Journal of Community Genetics - Category: Genetics & Stem Cells Source Type: research
Psychological stress alters TH17 cell response to gut microbiome and triggers acute vascular-occlusion induced by aged-neutrophils in sickle cell disease.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Editors ' Choice Source Type: research
Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Heel-prick tests are already used in Britain to check for nine rare but serious conditions, including cystic fibrosis and sickle cell disease. Scientists are pushing for diabetes to be added.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Condition:   Sickle Cell Disease Intervention:   Other: Questionnaire to assess needs Sponsors:   Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus;   Barau Dikko Teaching Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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