NICE unlicensed medicine evidence summary: topical diltiazem hydrochloride (2%) for chronic anal fissure

Source: NICE Area: Evidence > Drug Specific Reviews NICE unlicensed medicine evidence summary: topical diltiazem hydrochloride (2%) for chronic anal fissure   These evidence summaries review the published data for selected unlicensed or off-label medicines that are considered to be of significance to the NHS, where there are no clinically appropriate licensed alternatives. The summaries provide information for clinicians and patients to inform their decision-making and support the construction and updating of local formularies.   The latest summary addresses the use of topical diltiazem hydrochloride for treating chronic anal fissure. One Cochrane systematic review (4 RCTs; assessed as up-to-date November 2011) and 5 additional RCTs provide the evidence for this summary.   Key points include:   . The Cochrane review and 2 additional RCTs found that the efficacy of 2% topical diltiazem hydrochloride was not statistically significantly different from topical glyceryl trinitrate in ...
Source: NeLM - Drug Specific Reviews - Category: Drugs & Pharmacology Source Type: news