Two new diarylheptanoids from the green husks of Juglans regia L. and their cytotoxic activities

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Yue-Xian Jin, Xiao-Ling Ma, Hong-Yan Wei, Xiong-Fei Guo, Guo-Xu Ma, Lei-Ling Shi, Jing ZhangAbstractTwo new diarylheptanoids, 3- hydroxy- 3′,4″- epoxy- 1- (4′- methoxyphenyl) - 7- (3″- hydroxylphenyl)– heptane (1) and 2,3- dihydroxy- 1- (4′- hydroxy- 3′- methoxyphenyl)- 7- (4″- hydroxyphenyl)– heptanes (2), along with two known compounds, JuglaninB (3) and 4,17- dimethoxy- 2- oxatricyclo [13.2.2.13,7] eicosa- 3,5,7 (20),15,17,18- hexaene- 10,16- diol (4), were isolated from the green husks of Juglans regia L. Their structures were elucidated using1D and 2D NMR spectroscopic methods, HRESIMS, and CD spectra. Against MCF-7, compounds 1–4 have moderate cytotoxic activity, ranging from 11.4–32.7 μg · mL−1, compared with 31.9 μg · mL−1 forthe positive control cisplatin.Graphical abstract

Source: Phytochemistry Letters - May 25, 2019 Category: Chemistry Source Type: research