Psychogenic Pseudo-responses in an Electrical Cortical Stimulation.
Psychogenic Pseudo-responses in an Electrical Cortical Stimulation. Neurol Med Chir (Tokyo). 2019 May 22;: Authors: Tamada T, Enatsu R, Suzuki Y, Yokoyama R, Suzuki H, Ochi S, Mikuni N Abstract An electrical cortical stimulation provides important information for functional brain mapping. However, subjective responses (i.e. sensory, visual, and auditory symptoms) are purely detected by patients' descriptions, and may be affected by patients' awareness and intelligence levels. We experienced psychogenic responses in the electrical cortical stimulation of two patients with intractable epilepsy. A sham stimulation was useful for differentiating pseudo-responses from real responses in the electrical cortical stimulation. Inductive questions, long testing durations, and clear cues of stimulation onsets need to be avoided to prevent psychogenic pseudo-responses in the electrical cortical stimulation. Furthermore, a sham stimulation is applicable for detecting pseudo-responses the moment patients show atypical or inexplicable symptoms. PMID: 31118362 [PubMed - as supplied by publisher]
ConclusionsOur casuistic represents the first Epilepsy Monitoring Unit based case series of SUDEP conducted in Spain. The incidence in our population agrees with the reported in other countries. However, in our population, SUDEP is probably underdiagnosed due to administrative and legal issues.
Publication date: Available online 15 June 2019Source: SeizureAuthor(s): Lifang Dai, Changhong Ding, Fang Fang
In conclusion, although CBL did not exert an anticonvulsant effect against secondarily generalized seizures, it can be proposed for use as an add-on therapy in epilepsy management to prevent neuronal alterations, and to improve memory and learning processes.
DiscussionThe use of reference proconvulsive compounds and AEDs validated the electrophysiological parameters to detect proconvulsive risk. Systematic evaluation of compounds with the 3 complementary endpoints increase the probability to detect seizure liability in vitro. Depending on the compound mechanism of action, only one or two of the identified parameters might be modified.
Oddo S, Kochen S Abstract Purpose: Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits. Methods: Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included. Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured...
Abstract Anxiety and depression in children and adolescents with epilepsy are common comorbidities which place a significant burden on patients and families and complicate the clinical management of epilepsy. This paper presents a narrative review on the aetiology, phenomenology, assessment, and management of depression and anxiety among paediatric patients with epilepsy. The recognition of affective comorbidity in paediatric epilepsy is limited at present, and the contributory role of antiepileptic medication towards such comorbidity must be considered by clinicians. PMID: 31191736 [PubMed - in process]
ConclusionSelf-management may be effective in improving for quality of life in adult epileptics. However, these findings should be interpreted with caution due to the methodological quality of included trials. Furthermore, strict trials with precise methodological design and rigorous reporting on clinical efficacy and adverse events controlling self-management for epilepsy may be promising.
We present the first data showing aluminium in brain tissue in epilepsy and suggest, in light of complementary evidence from scientific literature, the first evidence that aluminium played a role in the advent of this case of late-onset adult epilepsy.
Treatments for prostate cancer and epilepsy are among commonly prescribed medicines that were stolen from Italian hospitals and sold to unwitting UK pharmacies.
Authors: Wang XF, Ge TT, Fan J, Yang W, Li B, Cui RJ Abstract [This corrects the article DOI: 10.18632/oncotarget.20606.]. PMID: 31191827 [PubMed - in process]