Review: Intensive blood pressure control reduces stroke, but not mortality or MI, in type 2 diabetes.

CONCLUSION Intensive blood pressure control reduced stroke, but not myocardial infarction or mortality, compared with standard control in adults with type 2 diabetes.Intensive vs standard blood pressure (BP) targets in adults with type 2 diabetes*OutcomesNumber of trials (n)†Weighted event ratesMean follow-up 2 to 5 yIntensive BP targetStandard BP targetRRR (95% CI)NNT (CI)Mortality5 (6812)5.1%6.4%20% (-14 to 44)Not significantMyocardial infarction4 (6683)8.9%9.6%7% (-9 to 21)Not significantStroke4 (6683)1.9%3.1%39% (17 to 55)82 (58 to 188)*Abbreviations defined in Glossary. Weighted intensive BP target event rate, RRR, NNT, and CI calculated from control event rates and risk ratios in article using a random-effects model.†To avoid double-counting the intensive BP target group in the HOT study, the meta-analyses presented in this abstract exclude the HOT diastolic ≤ 80 mm Hg vs ≤ 85 mm Hg comparison; the results are slightly different quantitatively compared with the source article, but the overall conclusions are unchanged. PMID: 23318339 [PubMed - in process]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research