IL-33-induced atopic dermatitis-like inflammation in mice is mediated by group 2 innate lymphoid cells in concert with basophils

IL-33 is a pro-inflammatory cytokine that plays a pivotal role in allergic disorders. In a transgenic mouse expressing IL-33 driven by a keratin-14 promoter (IL33tg), atopic dermatitis (AD)-like inflammation develops spontaneously with the activation of group 2 innate lymphoid cells (ILC2s). However, it remains unknown how effector cells, such as Th2 cells, ILC2s, and basophils, contribute to the inflammatory process induced by IL-33. To address the question, we examined the phenotype of IL33tg mice lacking each of these cells.

Source: Journal of Investigative Dermatology - May 20, 2019 Category: Dermatology Authors: Yasutomo Imai, Koubun Yasuda, Makoto Nagai, Minori Kusakabe, Masato Kubo, Kenji Nakanishi, Kiyofumi Yamanishi Tags: Original Article Source Type: research