Mesoporous SiO2 (SBA-15) modified graphite electrode as highly sensitive sensor for ultra trace level determination of Dapoxetine hydrochloride drug in human plasma

Publication date: Available online 16 May 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Hanaa El-Desoky, Mohamed Abdel-Galeil, Aya KhalifaAbstractMesoporous silica materials are considered highly popular in electroanalysis field especially Santa Barbara Amorphous type; SBA-15. Due to its extensive properties, SBA-15 was synthesized and utilized for construction of a simple and an inexpensive modified graphite sensor. This was done by hand mixing of different percentages of as-prepared SBA-15 with graphite powder as a conductor and Nujol oil as a binder until achieving homogenous carbon paste (CP). The as-prepared SBA-15 was characterized using TEM, SEM, EDX, XRD, BET N2 sorption isotherm and FTIR. In addition, electrochemical impedance spectra (EIS) and cyclic voltammetric measurements were used to characterize modified carbon paste electrode. They indicate lowest charge transfer resistance and highest effective surface area of the constructed 10%(w/w) SBA-15/CPE. This sensor exhibited also excellent electrocatalytic activity towards electrochemical oxidation of Dapoxetine hydrochloride (DPX.HCl). The applied SW-AdASV method shows also the efficiency of this sensor for DPX.HCl determination in its formulation and human plasma. Low value of the detection limit (LOD) of 2.45 × 10−10 M and wide linearity range (9 × 10−10 M to 1 × 10−8 M) in human plasma confirm the validity of the 10%(w/w) SBA-15/CPE as a sensor for quality control analy...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research