Tennis star Nicole Gibbs withdraws from French Open after dentist spotted a rare cancer in her mouth

Nicole Gibbs, 26, was at a routine dentist's appointment last month when the doctor spotted a growth on the roof her mouth, which was soon discovered to be salivary gland cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In this study, we added 11 years of follow-up (1958-2009), used improved radiation dose estimates, considered effects of smoking and alcohol consumption and performed dose-response analyses by anatomical sub-site. In examining 52 years'worth of data, we ascertained the occurrence of 394 oral cavity/pharyngeal cancers, 486 esophageal cancers and 5,661 stomach cancers among 105,444 subjects. The radiation risk for oral cavity/pharyngeal cancer, other than salivary gland, was elevated but not significantly so. In contrast, salivary gland cancer exhibited a strong linear dose response with excess relative risk (ERR) of 2.54 pe...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The aim of this study was to correlate the apparent diffusion coefficient (ADC) with histopathological parameters of salivary gland cancer. A retrospective analysis of 44 patients with salivary gland cancer who underwent diffusion-weighted magnetic resonance imaging of salivary glands was performed. The ADC of salivary gland cancer was correlated with pathological tumour type and grade, stage (T stage and N stage), and morphological (perineural spread and location) prognostic parameters. There was a significant difference in ADC values between low –intermediate- and high-grade tumours (P = 0.024), lower...
Source: International Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Clinical Paper Source Type: research
ConclusionsThis study showed that the NLR may serve as a useful prognosticator for a high risk of multiple recurrences in patients with ACC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
AbstractObjectivesThe aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.Material and methodsImmunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.ResultsExpression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%),...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
ConclusionsThis study shows, that NLR may serve as a useful prognosticator for a high risk of multiple recurrences in ACC patients.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study was to investigate the role of such markers in patients with ACC.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Oral and Maxillofacial SurgerySe Source Type: research
The androgen receptor (AR) is a nuclear steroid receptor that binds to testosterone and dihydrotestosterone and regulates the transcription of genes leading to cell growth, differentiation and survival. AR serves as an important oncogenic signal in prostate cancers and apocrine breast cancers. Salivary duct carcinoma (SDC) is a rare subtype of head and neck cancer that is defined by an apocrine phenotype, with AR positivity by immunohistochemistry (IHC) in up to 98% of cases [1]. A recent clinical trial with leuprorelin acetate and bicalutamide has shown promising activity with an overall response rate of 42% in AR-positiv...
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Letter to the editor Source Type: research
Salivary gland cancers comprise a wide histological spectrum with more than twenty different subtypes [1]. In 2010, a new entity of salivary gland cancer was described by Sk álová et al., characterized by the presence of the ETV6-NTRK3 fusion gene [2]. The histopathological appearance resembles secretory carcinoma of the breast, and both tumors share the ETV6-NTRK3 fusion gene, hence the proposed name was mammary analogue secretory carcinoma (MASC). In the updated 201 7 WHO classification, MASC is acknowledged and referred to as ‘secretory carcinoma’, to standardize nomenclature amongst different organ sites [1].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
The major salivary glands occur in three pairs (the parotid, submandibular, and the sublingual glands), while the minor salivary glands occur as several hundred structures scattered within the mucous membranes of the mouth, oropharynx, larynx, nose, and the paranasal sinuses. In France, the cancers of the major salivary glands are rare, with an estimated incidence of 0.7/100,000 person-years in men and 0.5/100,000 person-years in women [1], and account for 1.9% and 8.6% of head and neck cancers (HNC) in men and in women, respectively [2].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research
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