Girl, 5, suffers from rare disease triggered by the sun that could leave her covered in rashes

Kaia Ettingoff, five, of Wayne, Pennsylvania, was diagnosed in January 2018 with juvenile dermatomyositis, a rare autoimmune disorder that leaves her with rashes and muscle inflammation.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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OBJECTIVE: Primary Sj ögren ’ s syndrome (pSjS) is a chronic autoimmune disease that causes dry eye and mouth. No laboratory parameters to monitor the activation of this disease have been identified. Therefore, any possible relationships between salivary and blood myxovirus resistance 1 (MX1) and pSjS must be prospectively studied. METHODS: Thirty female patients with pSjS, 30 women with rheumatoid arthritis (RA) without secondary Sj ögren ’ s syndrome (SjS) and 28 healthy control women were enrolled in this investigation. Analyses of MX1 by the enzyme-linked immunosorbent assay (ELISA) method, SS-A (...
Source: Clinics - Category: General Medicine Source Type: research
No abstract available
Source: Pancreas - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Authors: Khattab H, Rafai MA, El Moutawakil B, El Otmani H, Mikou N, Bouayed K PMID: 31208812 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Anyone who remembers the days before finger stick blood glucose meters became available to people with diabetes will recall how awful life was for diabetics. All they had was urine dipsticks which were sloppy, yielded only crude non-quantitative feedback on blood sugars, and gave you a gauge of what blood sugars were in the recent past, not the present. It meant that dosing insulin or diabetes drugs was grotesquely imprecise and accounted for many episodes of hypoglycemic coma and acceleration of diabetic complications. It was not uncommon in those days, for instance, for a type 1 diabetic to be blind and experience kidney...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO bowel flora Inflammation probiotic undoctored wheat belly Source Type: blogs
Publication date: 18 June 2019Source: Cell Reports, Volume 27, Issue 12Author(s): Bi-Huei Yang, Ke Wang, Shuo Wan, Yan Liang, Xiaomei Yuan, Yi Dong, Sunglim Cho, Wanqing Xu, Kristen Jepsen, Gen-Sheng Feng, Li-Fan Lu, Hai-Hui Xue, Wenxian FuSummaryCD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg’s differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient expression of TCF1 and LEF1 distinguishes Tregs into three di...
Source: Cell Reports - Category: Cytology Source Type: research
We present the first clinical description of a patient with superficial siderosis and hemophilia as the trigger of bleedings. Brain MRI was crucial for diagnosis.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Dermatomyositis (DM) is part of a group of rare diseases classified as idiopathic inflammatory myopathies, autoimmune origin. The main clinical manifestations are the weakness of the muscles and the presence of skin lesions, which may progress to severe systemic changes. The most common treatment is based on the use of corticosteroids and immunosuppressant. A female patient, 64 years old, diagnosed with diabetes and chronic use of prednisone 60 mg/day, showed osteonecrosis in the jaw after tooth extractions and spontaneously in the jaw, causing her hospitalization.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: CPP - Clinical Poster Presentation Source Type: research
This article provides guidelines for diagnosing and treating the different subtypes of autoimmune myopathies. Recent Findings: The most common subtypes of autoimmune myopathies are dermatomyositis, immune-mediated necrotizing myopathy, antisynthetase syndrome, and overlap syndromes; isolated polymyositis is an exceptionally rare disease. Specific autoantibodies are associated with unique clinical phenotypes and may be used for diagnostic and prognostic purposes, such as to assess the risk of coexisting malignancy. Summary: Diagnosing the specific subtype of autoimmune myopathy can be achieved by combining relevant featur...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: Review Articles Source Type: research
Dermatomyositis is an autoimmune myopathy characterized by proximal muscle weakness, muscle inflammation, and typical skin findings. It is a rare disease with  an incidence of ~1/100 000. About 15–30 % of adult...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Source Type: research
Objectives The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. Results The huma...
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Genetics, Immunology (including allergy), Muscle disease, Interstitial lung disease, Connective tissue disease, Musculoskeletal syndromes Basic and translational research Source Type: research
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