Progestogen Intolerance (in MHT): what are the options?

Progestogens have a variety of effects apart from the one for which their use was intended, that of secretory transformation of the endometrium. Symptoms of fluid retention are produced by the sodium retaining effect of the renin-aldosterone system which is triggered by stimulation of mineralocorticoid receptors. Androgenic side effects such as acne and hirsuitism are a problem of the testosterone derived progestogens due to stimulation of the androgen receptors. Mood swings and PMS-like side effects result from stimulation of the central nervous system progesterone receptors.

Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Nick Panay Tags: INV28 Source Type: research