Mozambique: Malaria Killed 360 People Between January and April in Mozambique

[Verdade] Malaria remains the leading cause of death in Mozambique, between January and April of this year the Ministry of Health recorded 360 deaths among the 2,961,429 cases it registered. Most of the deaths were recorded in the provinces of Niassa, Cabo Delgado and Zamb ézia.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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Condition:   Malaria Intervention:   Biological: PfSPZ Vaccine Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
[Ghanaian Times] A high level stakeholders meeting is underway to review Ghana's efforts at reducing the malaria burden under the new "high burden to high impact (HBHI)" approach.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Retinal manifestations of neuro-malaria or "malarial retinopathy" in Yaoundé]. J Fr Ophtalmol. 2019 Jun 12;: Authors: Koki G, Ngoulou W, Nomo AF, Nguefack S, Epee E, Bella AL Abstract AIM: Contribute to the improvement of diagnostic and prognostic approaches to treating children with neuro-malaria in Yaoundé. PATIENTS AND METHOD: A prospective and analytical study carried out in 2 hospitals of Yaoundé from October 2015 to March 2016. All patients aged 3 months to 15 years hospitalized for neuro-malaria in one of the 2 hospitals benefited from...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
In this study, we phenotypically characterized the expression of T cell inhibitory(PD-1, CTLA-4) and senescent markers (CD28(-), CD57) from children with symptomatic malaria, asymptomatic malaria and healthy controls using flow cytometry. We observed increased expression of T cell exhaustion and senescence markers in the symptomatic children compared to the asymptomatic and healthy controls. T cell senescence markers were more highly expressed on CD8 T cells than on CD4 T cells. Asymptomatically infected children had comparable levels of these markers with healthy controls except for CD8+ PD-1+ T cells whose levels were s...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsOur findings confirm that helminth polyparasitism and co-infection with major diseases is common in the tropics. A multitude of factors acting at various hierarchical levels, such as interspecies interactions at the within-host infra-parasite community level and environmental variables at the higher host community level, could explain the observed positive associations between pathogens; there remains a need to develop new frameworks which can consider these multilevel factors to better understand the processes structuring parasite communities to accomplish their control.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
[WHO] A new scorecard -- the first to examine hepatitis prevalence and response in the World Health Organization (WHO) African region, shows that only three of the 47 countries are on track to eliminate the disease that affects one in 15 people in the region. Dying of viral hepatitis in Africa is becoming a bigger threat than dying of AIDS, malaria or tuberculosis.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Tackling relapsingPlasmodium vivax and zoonoticPlasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the lack of robust molecular and genetic approaches. Here, we establish CRISPR-Cas9 genome editing in a culture-adaptedP. knowlesi strain and define parameters for optimal homology-driven repair. We establish a scalable protocol for the production of repair templates by PCR and demonstrate the flexibility of the system by tagging proteins with distinct cellular localisations. Using ite...
Source: eLife - Category: Biomedical Science Tags: Genetics and Genomics Microbiology and Infectious Disease Source Type: research
CONCLUSION: Additional simple-to-use diagnostic tests as well as additional training in patient examination and clinical assessment are needed in rural settings where health providers risk over-prescribing antibiotics or missing a potentially dangerous infection in febrile patients who test negative for malaria. PMID: 31200600 [PubMed - in process]
Source: Rural and Remote Health - Category: Rural Health Tags: Rural Remote Health Source Type: research
Authors: Kułak-Bejda A, Waszkiewicz N, Bejda G, Zalewska A, Maciejczyk M Abstract A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabolites. Saliva collection is noninvasive, and self-collection is possible. There is a lack of risk of injuries related to injection with needle, and it is generally safe. Human saliva has been successfully used, for exampl...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: Available online 13 June 2019Source: CellAuthor(s): Daniel G.W. Alanine, Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R. Donnellan, Nana K. Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E. Silk, Abhishek Jamwal, Jennifer M. Marshall, Kazutoyo Miura, Lander Foquet, Sean C. Elias, Geneviève M. Labbé, Alexander D. Douglas, Jing Jin, Ruth O. Payne, Joseph J. IllingworthSummaryThe Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However...
Source: Cell - Category: Cytology Source Type: research
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