Is More Better? Promising Biological Effects of Double-Dose Alpha 1-Antitrypsin Therapy.

Is More Better? Promising Biological Effects of Double-Dose Alpha 1-Antitrypsin Therapy. Am J Respir Crit Care Med. 2019 May 07;: Authors: Petrache I PMID: 31063431 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research

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In conclusion, occupational exposure toAspergillus may cause different effects on immunological parameters related to respiratory problems in ceramic workers.
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Alpha 1 Antitrypsin (AAT) is a key serum proteinase inhibitor encoded by SERPINA1. Sequence variants of the gene can cause Alpha 1 Antitrypsin Deficiency (AATD), a condition associated with lung and liver disease...
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The characteristics of nontuberculous mycobacterial pulmonary disease (NTM-PD) in individuals without clinically apparent predisposing factors have been described in female-predominant cohorts. Phenotypic characteristics are advanced age, tall stature, slender body habitus, right middle lobe (RML)- and/or lingula-predominant nodular bronchiectasis, and increased frequencies of scoliosis, pectus excavatum (PEX) and mitral valve prolapse [1–3]. Increased rates of cystic fibrosis transmembrane conductance regulator (CFTR), immune, ciliary and connective tissue gene mutations, and abnormal α1-antitrypsin (α1-...
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Authors: Wells AD, Woods A, Hilleman DE, Malesker MA Abstract Chronic obstructive pulmonary disease can be attributed to genetic conditions and predispositions, among other factors. Alpha-1 antitrypsin deficiency (AATD) is a significant risk factor for COPD development and progression, and aggressive screening for all patients with COPD or adult-onset asthma is encouraged. PMID: 31258312 [PubMed]
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Abstract Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. In Taiwan, OSCC is the fifth leading cause of cancer-related mortality and leads to 2800 deaths per year. The poor outcome of OSCC patients is principally ascribed to the fact that this disease is often advanced at the time of diagnosis, suggesting that early detection of OSCC is urgently needed. Analysis of cancer-related body fluids is one promising approach to identify biomarker candidates of cancers. To identify OSCC biomarkers, salivary proteomes of OSCC patients, individuals with oral potentially malignant disord...
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In this study, we examined the proteome profile of tear samples from A. flavus keratitis patients at various stages of infection. The proteome was profiled using 2D PAGE and the protein levels were quantified using 2D DIGE. Alpha-1-antitrypsin, apolipoprotein, haptoglobin, lactoferrin and albumin were up regulated while cystatin SA III precursor, lacrimal lipocalin precursor, lacritin precursor and Zinc alpha-2 glycoprotein (ZAG) were down regulated in tear fluid. In the case of ZAG all proteoforms were down regulated as the disease progressed from early to late stage of infection. Western blot analysis confirmed the resul...
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Conclusion: Our results suggest that AAT is internalized by β cells through clathrin-mediated endocytosis that leads to the suppression of caspase 9 activation. This process is required for the protective function of AAT in islets when challenged with proinflammatory cytokines or after islet transplantation.
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