Airway Histopathology of Adolescent Survivors of Bronchopulmonary Dysplasia
Long-term survivors of bronchopulmonary dysplasia develop chronic obstructive lung disease. Herein we report in vivo histopathology from bronchial biopsies of 3 adolescent survivors of severe bronchopulmonary dysplasia. Thickened basement membranes with lymphocytic infiltrates and signs of immature neoangiogenesis in the absence of T-helper lymphocytes or eosinophils suggest the presence of an ongoing activ e airway process.
Journal of Perinatology, Published online: 07 November 2019; doi:10.1038/s41372-019-0548-xHospitalization costs associated with bronchopulmonary dysplasia in the first year of life
Bronchopulmonary dysplasia (BPD) is the most common serious complication associated with preterm birth. Infants with severe BPD often require prolonged and intensive pulmonary care. Among those with the most severe lung disease, this care may include tracheostomy and long-term invasive mechanical ventilation. Although there is a plethora of data on long term respiratory and developmental outcomes of BPD survivors, relevant information on BPD survivors requiring chronic respiratory failure are limited.
Conclusion Infants are exposed to a large number of medications during NICU hospitalization, including potentially unnecessary antibiotics and reflux medications. Male sex, the presence of certain comorbidities such as necrotizing enterocolitis, and LOHS, are associated with higher exposure. Increased awareness of this issue may assist in decreasing medication exposure in VLBW populations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text
This article aims to determine the incidence of short-term complications of surgical patent ductus arteriosus (PDA) ligations, the factors associated with those complications, and whether complications are associated with poor long-term outcomes. Study Design Retrospective cohort study of all extremely low birth weight (ELBW,
CONCLUSIONS: Although PH did not extend hospital stay or increase the risk of bronchopulmonary dysplasia, it increased the mortality and intraventricular hemorrhage rate in ELBWIs. EOS was the independent risk factor for PH in ELBWIs. PMID: 31686366 [PubMed - as supplied by publisher]
Publication date: Available online 2 November 2019Source: Clinica Chimica ActaAuthor(s): Fiammetta Piersigilli, Vineet BhandariAbstractThe pathogenesis of Bronchopulmonary dysplasia (BPD) remains poorly understood. It is a multifactorial disease having a genetic-environmental basis. Although attempts have been made to identify a biomarker, none have been validated for clinical use to date. Metabolomics is a promising field of the “omics technologies” that could allow for better understanding of the pathogenesis and underlying mechanisms of BPD as well as facilitate detection of biomarkers. Identification of the...
Abstract The pathogenesis of Bronchopulmonary dysplasia (BPD) remains poorly understood. It is a multifactorial disease having a genetic-environmental basis. Although attempts have been made to identify a biomarker, none have been validated for clinical use to date. Metabolomics is a promising field of the "omics technologies" that could allow for better understanding of the pathogenesis and underlying mechanisms of BPD as well as facilitate detection of biomarkers. Identification of these biomarkers would improve diagnosis, identify patients in early disease stages and potentially target intervention. T...
Journal of Perinatology, Published online: 28 October 2019; doi:10.1038/s41372-019-0540-5Impact of tracheostomy on language and cognitive development in infants with severe bronchopulmonary dysplasia
PMID: 31658423 [PubMed - as supplied by publisher]
This study aimed to assess whether 17-OHPC decreases recurrent PTB and neonatal morbidity in women with a prior SPTB in a singleton gestation. Study Design This was a double-blind, placebo-controlled international trial involving women with a previous singleton SPTB (clinicaltrials.gov: NCT 01004029). Women were enrolled at 93 clinical centers (41 in the United States and 52 outside the United States) between 160/7 to 206/7 weeks in a 2:1 ratio, to receive either weekly intramuscular (IM) injections of 250 mg of 17-OHPC or an inert oil placebo; treatment was continued until delivery or 36 weeks. Co-primary o...