AstraZeneca Starts Artificial Intelligence Collaboration to Accelerate Drug Discovery

AstraZeneca and BenevolentAI began a long-term collaboration to use artificial intelligence (AI) and machine learning for the discovery and development of new treatments for chronic kidney disease (CKD) and idiopathic pulmonary fibrosis (IPF).
Source: eHealth News EU - Category: Information Technology Tags: Featured Industry Business and Industry Source Type: news

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Authors: Garla VV, Kanduri S, Yanes-Cardozo L, Lien LF Abstract Diabetes mellitus (DM) and Chronic Kidney Disease (CKD) are two chronic diseases whose prevalence and co-prevalence are on the rise. CKD is also the most debilitating and expensive complication of DM while management of DM in CKD is most challenging. CKD is developing in much younger patients with DM, and its presentation is also changing. Various methods of glycemic assessment are affected by CKD and dosage of DM medications needs to be adjusted according to the kidney function. One of the significant barriers to glycemic control in DM patients with C...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Abstract Acute kidney injury (AKI) is a frequent and serious complication of orthotopic liver transplantation (OLT), with a significant impact on mortality, graft survival, and chronic kidney disease. Currently, the diagnosis of AKI is based on changes in serum creatinine, which is a late marker, usually rising when there is already significant damage to the renal parenchyma. During the last 2 decades, various biomarkers have been studied in many clinical situations, mostly after cardiac surgery, in drug-induced AKI, or in sepsis. The present article summarizes the data on those biomarkers that have been evaluated...
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: ORIGINAL ARTICLE Source Type: research
Purpose Research examining the relationship between physical activity (PA) and cardiovascular disease (CVD) risk factors among kidney transplant recipients (KTR) is limited. Accordingly, we sought to 1) describe the levels of PA in KTR and 2) analyze the associations between PA levels and CVD risk factors in KTR. Methods Baseline data from KTR participants in a large multiethnic, multicenter trial (the Folic Acid for Vascular Outcome Reduction in Transplantation) were examined. PA was categorized in tertiles (low, moderate, and high) derived from a modified PA summary score from the Yale Physical Activity Survey. CVD ...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research
We examined the effects of human mesothelial cell (MC) sheets and hepatocyte growth factor (HGF)-transgenic mesothelial cell (HGF-tg MC) sheets transplanted under the renal capsule in an IRI rat model, and compared these two treatments with the intravenous administration of HGF protein and no treatment through serum, histological, and mRNA analyses over 28 days. The MC sheets and HGF-tg MC sheets produced HGF protein and significantly improved acute renal dysfunction, acute tubular necrosis, and survival rate. The improvement in necrosis was likely due to the cell sheets promoting the migration and proliferation of renal t...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Conclusion: Oral sodium bicarbonate supplementation showed no effect on T50-time in acidotic CKD patients.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
Abstract The mechanism responsible for the decreased extra-renal CYP3A activity in chronic kidney disease (CKD) patients remains unknown. Using an animal model, we previously found that elevated levels of serum intact parathyroid hormone (iPTH) caused a reduced CYP3A activity. This retrospective observational study assessed the relationship between serum iPTH levels and the blood concentration or dosage of tacrolimus, a CYP3A substrate, after oral administration in kidney transplant patients. Thirty-four patients were enrolled who had kidney transplants between April 2014 and March 2016 and who had been administra...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Causland FR Abstract PURPOSE: Diabetes mellitus is a risk factor for the development and progression of chronic kidney disease (CKD). However, the association of prediabetes with adverse kidney outcomes is uncertain. METHODS: We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), including 9,361 participants without diabetes at baseline. We categorized participants according to fasting glucose as having impaired fasting glucose (≥100 mg/dL [(≥5.6 mmol/L]) or normoglycemia (
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
I seem to have lost track of advancements in dipstick technology understanding that it is well established in such areas as pregnancy testing. Home glucose testing for diabetics, of course, is growing increasingly sophisticated with the test strips beingread by a meter. A recent article indicated that this meter technology can be replaced by the camera in a smartphone for recording and analyzing dipstick color changes when screening for kidney disease (see:FDA approves smartphone camera –based dipstick product). Below is an excerpt from the article:, based in Tel Aviv, Israel, has obtained U...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Industry News Clinical Lab Testing Diagnostics Food and Drug Administration Healthcare Information Technology Healthcare Innovations Lab Industry Trends Lab Processes and Procedures Medical Consumerism Medical Research Poi Source Type: blogs
We reported a preliminary analysis of its genome organization and gene content, including gene annotations, GC content, repeat elements and SSRs. Subsequently, phylogenetic analysis, motif analysis and exon-intron organization of some important genes were also investigated. We believe the S. japonica genome generated in this study will enhance both fundamental and applied research in related areas. Materials and Methods Sample Collection and DNA Preparation A thermotolerant and high-yielding Saccharina cultivar “Rongfu” was selected as the genomic DNA source for whole genome sequencing. Samples were collecte...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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