Premature birth is linked to increased risk of chronic kidney disease into later life

Source: BMJ News - Category: General Medicine Source Type: research

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Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Rebecca Rodin, Christopher T. ChanAbstractChronic kidney disease (CKD) is associated with premature cardiovascular morbidity and mortality. Traditional Framingham risk factors contribute partially to the malignant form of cardiovascular disease (CVD) in CKD. Uremic specific risk factors including: chronic inflammation, retention of uremic toxins and abnormal bone mineral metabolism have independently been linked to the pathogenesis of premature vascular aging, atherosclerosis, and CVD. This review will explore the mechanisms by w...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Chillo P, Ismail A, Sanyiwa A, Ruggajo P, Kamuhabwa A Abstract Background: Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili Nationa...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
ConclusionsPatients in intermediate stages do not receive follow-up with a multidisciplinary team at the recommended frequency. The preventive approach of the progression of renal disease in the intermediate stage in the studied municipality was not within the recommendations of the Ministry of Health.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
There are three reasons to generate a new human kidney. The first is to learn more about the biology of the developing and mature organ. The second is to generate tissues with which to model congenital and acquired kidney diseases. In particular, growing human kidneys in this manner should ultimately help to understand the mechanisms of common chronic kidney diseases such as diabetic nephropathy and others featuring fibrosis, as well as nephrotoxicity. The third is to provide functional kidney tissues that can be directly used in regenerative medicine therapies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Prematurity is associated with a greater risk of developing chronic kidney disease into mid-adulthood, and preventive action is needed for all babies born earlier than full term.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
The impact of adverse maternal and early gestational issues, ranging from maternal –fetal interactions all the way through to premature birth, are recognized as having influence on the subsequent development of chronic diseases later in life. The development of chronic kidney disease (CKD) as a direct result of early life renal injury or a sequela of diseases such as hypertensio n or diabetes is a good model example of the potential impact that early life events may have on renal development and lifelong function.
Source: Seminars in Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Conclusions Proteinuria in both patients was caused by glomerular hypertension with hyperfiltration. Extremely preterm birth itself may be a risk factor for future CKD. Long-term follow-up of patients born prematurely and at low birth weight, including urinalysis and blood pressure measurements, is necessary to diagnose and treat late renal complications.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study examines nine pregnant women with severe CKD (defined as estimated GFR
Source: Clinical Nephrology - Category: Urology & Nephrology Authors: Tags: Clin Nephrol Source Type: research
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