Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic-field hybrid cultivation systems II: comparison of serum concentration of glycyrrhetinic acid serum concentration in mice
AbstractTo evaluate the safety and efficacy ofGlycyrrhiza uralensis root produced using artificial hydroponic and artificial hydroponic-field hybrid cultivation systems, we investigated the pharmacokinetics of a major metabolite of glycyrrhizin (GL), glycyrrhetinic acid (GA). Hot water extracts obtained from the roots of the artificial hydroponic-field hybrid cultivatedGlycyrrhiza uralensis were orally administered at a dose of 100 mg/kg as GL in mice and, compared with a commercial crude drug, Glycyrrhizae Radix. The temporal changes in serum GA concentration was found to depend on the GL concentration of the hot-water extracts. When hot-water extracts containing relatively high GL were administered, bimodal peaks appeared. In contrast, a broad single peak was detected when a hot-water extract containing relatively low GL content was administered. These tendencies in the serum GA concentration time course were observed for all samples, regardless of their derivation. Moreover, we compared the pharmacokinetic parameter s and found that theCmax and AUC0 –48 values after oral administration of the extracts fromGlycyrrhiza uralensis roots produced by the artificial cultivation system are within the range of variation for the commercial crude drugs. These results suggest the possibility that roots ofGlycyrrhiza uralensis cultivated by the artificial hydroponic-field hybrid cultivation system can be used in addition to currently available commercial crude drugs produce...
Conclusions: Results of the present study support the interpersonal theory of suicide, which suggests that self-reported thwarted belongingness can foster WD. Clinical implications: Clinicians should consider social dissatisfaction and withdrawal as risk factors for WD and design interventions that foster social skills or meaningful connections. PMID: 31615349 [PubMed - as supplied by publisher]
CONCLUSIONS: we found an association between SIBO and allergic disease, especially allergic rhinitis, cow's milk protein allergy and asthma. Thus, SIBO should be ruled out in pediatric patients with CAP and allergic disease. PMID: 31617366 [PubMed - as supplied by publisher]
CONCLUSIONS: this meta-analysis supported the association of AF with increased risk of GERD. PMID: 31617365 [PubMed - as supplied by publisher]
CONCLUSION: these data support the hypothesis that the hepatitis C virus may worsen quality of life in asymptomatic patients. PMID: 31617364 [PubMed - as supplied by publisher]
We report a case of a 67-year-old female presented with hematemesis eventually diagnosed with duodenal mucormycosis, while radiology characteristics suggested malignancy. PMID: 31617363 [PubMed - as supplied by publisher]
Authors: Taki S, Maekita T, Sakata M, Fukatsu K, Maeda Y, Iguchi M, Ito H, Kitano M Abstract Continuous duodenal levodopa/carbidopa intestinal gel delivery by a gastrostomy infusion system improves control of Parkinson's disease. The overall complication rates of percutaneous endoscopic gastrojejunostomy were reported to be 41% and 59% for immediate and delayed adverse events, respectively. A 72-year-old woman underwent percutaneous endoscopic gastrojejunostomy using the delivery system noted above. Abdominal pain and vomiting occurred 3 months later. Esophagogastroduodenoscopy showed a longitudinal ulcer extending...
Conclusions: Our study is the first to report that endoscopic therapy of PFCs using LAMS is safe and effective even in a community hospital setting with limited resources and support compared to large academic centers. PMID: 31615198 [PubMed - as supplied by publisher]
Authors: Krill TS, Chatila A, Marcondes F, Samuel R, Guturu P, Parupudi S Abstract PMID: 31617699 [PubMed - in process]
Authors: Adu-Tei S, Penny HA, El-Fekhi M, Ruse C, Sanders DS Abstract PMID: 31617698 [PubMed - in process]
Authors: Ramai D, Shahnazarian V, Etienne D, Ayide G, Reddy M Abstract PMID: 31617697 [PubMed - in process]
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