Delineation of crosstalk between HSP27 and MMP-2/MMP-9: A synergistic therapeutic avenue for glioblastoma management

ConclusionThe association of HSP27 with MMP-2 and MMP-9 proteins along with the identified interacting stretch has the potential to contribute towards drug development to inhibit GBM infiltration and migration.General significanceCurrent findings provide a novel therapeutic target for GBM opening a new horizon in the field of GBM management.Graphical abstract

Source: Biochimica et Biophysica Acta (BBA) General Subjects - April 25, 2019 Category: Biochemistry Source Type: research