Characteristics and Outcomes of Patients With and Without Type 2 Diabetes Mellitus and Pulmonary Sepsis

To date, studies have provided conflicting results regarding the impact of type 2 diabetes mellitus (DM) on sepsis-related outcomes. Our objective is to understand the impact of type 2 DM in bacterial pneumonia and sepsis-related intensive care unit (ICU) outcomes. Our findings demonstrated that type 2 DM does not increase the overall mortality. Our findings of increased mortality in both type 2 DM patients with lower admission glucose, and non-DM patients with higher mean glucose during the hospital stay needs to be further evaluated. Future studies in regards to this could lead to personalized glucose treatment goals for patients.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Authors: Sarda C, Fazal F, Rello J Abstract Introduction: Treatment of ventilator-associated pneumonia (VAP) is a major challenge. The increase in multi-drug resistant bacteria has not been accompanied by the validation of new drugs, or by any new antimicrobial strategies to exploit the available agents. VAP due to Gram-negative bacteria has increased mortality, both due to the resistant pathogens themselves and due to inappropriate treatment. Local epidemiology, patients' characteristics and clinical responses provide the most important information for therapeutic decision-making. Moreover, data on VAP therapy due...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
This study was aimed to evaluate the antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of n-butanol extracts from leaves and flowers of Chrysanthemum fontanesii. β-carotene-linoleic acid, Galvinoxyl radical (GOR), ABTS, hydroxyl radical, reducing power, CUPRAC, O-phenanthroline and metal chelating assays were used to evaluate antioxidant capacity of the extracts. The extracts showed good antioxidant activity and were a good source of phenolics and flavonoids. The enzyme inhibitory activity of the extracts was investigated against key enzymes involved in neurodegenerative [acetylcholinesterase...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
A 71-year-old with Stanford type B aortic dissection treated with Cook Medical (Bloomington, IN) ProForm ™ stent grafts 3 years previously was referred to the nephrology outpatient clinic for asymptomatic new-onset renal impairment. Other comorbidities were chronic hepatitis B, diabetes mellitus, and hypertension. Clinic blood pressure was 152/80 mm Hg, but physical examination was otherwise unremar kable. Serum creatinine was 142 μmol/l, urine protein-to-creatinine ratio 4.07 g/g, and glomerular hematuria was present (210 red cells) without pyuria on urine microscopy.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
The sodium-dependent glucose cotransporters (SGLT) are a family of transporters on the luminal side of proximal tubular epithelial cells. SGLT2 normally reabsorbs approximately 90% of the filtered glucose load. SGLT2 is more abundantly expressed in proximal tubular epithelial cells in patients with type 2 diabetes mellitus (DM) than in healthy individuals, leading to excessive glucose reabsorption. SGLT2 inhibitors lower blood glucose by increasing urinary glucose excretion. The glucose-lowering effect is independent of insulin ( β-cell function and insulin sensitivity) and rarely causes hypoglycemia.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
We appreciate the letter by Dr.  Sugiyama, which provides a potential mechanistic insight with regard to the relationship between chronic kidney disease and fracture risk.1 We agree with Dr. Sugiyama that lower estimated glomerular filtration rate is associated with a decline in physical activity, and as such, physical activity c ould be a confounder in the relationship between chronic kidney disease and bone mineral density. In our previous work, we found a 4-fold higher risk of low physical activity with chronic kidney disease, a greater magnitude than diabetes or nearly 2 decades of aging.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Conclusions: Fasting and postprandial plasma glucose screening can replace gestational diabetes mellitus screening in women who refuse to have the glucose load test. PMID: 31210349 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - Category: Middle East Health Tags: East Mediterr Health J Source Type: research
In conclusion, OXTZD could be developed as a therapeutic agent for diabetes and/or serve as a lead compound for further drug design studies targeting PPAR-γ for effective management of type 2 diabetes without inducing weight gain. PMID: 31204468 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Publication date: Available online 18 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Ryota Shintani, Tsuneyuki Oda, Takashi Niwa, Akimasa Sekine, Eri Hagiwara, Koji Okudela, Tamiko Takemura, Takashi OguraAbstractA 53-year-old Japanese female was admitted to our hospital with 3-week history of cough and worsening dyspnea. Chest computed tomography revealed unilateral focal consolidation in the right lower lobe. She underwent transbronchial lung cryobiopsy (TBLC) and histology showed acute fibrinous and organizing pneumonia (AFOP). High-dose methylprednisolone treatment improved her respiratory condition and ra...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conclusion This evidence supports the need for specific nutritional guidelines for gestational hypertensive disorders, as well as great public attention for overweight women in the fertile age.Resumo Objetivo Diferentes ambientes intrauterinos podem influenciar a varia ção de peso corporal pré-gestacional materno até 6 meses pós-parto. O objetivo do presente estudo foi verificar a associação de fatores sociodemográficos, obstétricos, nutricionais e comportamentais com a variação de peso em mulheres divididas em quatro grupos: hipertensas (HM), dia...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Abstract The hypothesis of fetal origins to adult diseases proposes that metabolic chronic disorders, including cardiovascular diseases, diabetes, and hypertension originate in the developmental plasticity due to intrauterine insults. These processes involve an adaptative response by the fetus to changes in the environmental signals, which can promote the reset of hormones and of the metabolism to establish a “ thrifty phenotype ” . Metabolic alterations during intrauterine growth restriction can modify the fetal programming. The present nonsystematic review intended to summarize historical and current referenc...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
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