Cytotoxicity of cationic NHC copper(I) complexes coordinated to 2,2'-bis-pyridyl ligands

Publication date: Available online 21 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Margaux Elie, Gilbert Umuhire Mahoro, Eric Duverger, Jean-Luc Renaud, Richard Daniellou, Sylvain GaillardAbstractCytotoxicity of cationic (NHC)Cu(I) complexes bearing 2,2′-dipyridylamine (dpa) type ligands has been evaluated toward 4 cancer cell lines, and compared to the one of neutral (NHC)Cu(I) complexes. The high cytotoxicity of these novel cationic (NHC)Cu(I) complexes, combined with the straightforward synthesis, and versatility of dpa type ligands may offer new prospects in cancer research, toward the development of novel carrier linked prodrugs.Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research