Trypanocidal drug resistance: a threat to animal health and production in gidami district of kellem wollega zone, oromia regional state, western ethiopia

This study was conducted from May 08 to June 08, 2017 in Gidami District, KellemWollega Zone, Oromia Regional State, Ethiopia. The objective of the study was to assess the occurrence of trypanocidal drug resistance in naturally infected cattle in identified hot spots villages of Gidami district. An initial cross-sectional prevalence study was conducted in seven villages from November 2015 to June 2016. Based on the outcome of the cross-sectional study, Kellem and Gry Sonka villages with highest trypanosome prevalence (28% and 30.85%) respectively were selected. An abbreviated 28-day field prototocol study was used to estimate resistance to 1 mg/kg b.w isometamidium chloride (ISM) and 7.0 mg/kg b.w diminanzene aceturate (DA). In this study, 100 purposively selected trypanosome positive cattle were ear-tagged and allocated into two treatment groups: a group I were treated with 2% solution of 1 mg/kg b/w ISM and a group II were treated with 7% solution of 7 mg/kg b/w DA. The treatment day was considered as day 0 and the treated cattle were monitored for trypanosomes and packed cell volume (PCV) levels on days 14 (for DA and ISM) and 28 (for ISM) post treatment. A treatment failure rate of 25% of the cattle in the ISM treated group on days 14 and 28 were indicative of resistance, whereas in the DA treated group the response was assessed only on day 14 post-treatment. The results of the study confirmed the presence of drug resistance to the maximum recommended doses of ISM...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research