Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes.

Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes.
Chem Commun (Camb). 2019 Apr 18;:
Authors: Nakamura S, Tokunaga A, Saito H, Kondo M
Abstract
The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)-palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically active rolipram.
PMID: 30997446 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 17, 2019 Category: Chemistry Authors: Nakamura S, Tokunaga A, Saito H, Kondo M Tags: Chem Commun (Camb) Source Type: research