006 Topical application of caffeoyl prolyl histidine amide suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice

The main components in atopic dermatitis (AD) pathogenesis are skin barrier abnormality, immunologic dysregulation, and pruritus. Considering the oxidative stress impacts on three main factors, we hypothesized antioxidant agents could be an effective treatment option in AD. To evaluate the effect of caffeoyl-prolyl-histidine amide (CA-L-Pro-L-His-NH2; CA-PH), a conjugated amide form of caffeic acid, 2,4-dinitrochlorobenzene (DNCB) was topically applied on the dorsal skin of BALB/c mice to induce AD-like symptoms and cutaneous lesions.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research