076 IL-36 signaling is essential for psoriatic inflammation through the augmentation of innate immune responses

The IL-1 family member IL-36 consists of 3 agonists and 1 antagonist; IL-36 α, IL-36β, and IL-36γ and the receptor antagonist IL-36Ra, respectively. Psoriatic epidermis expresses them except IL-36β. In addition, it has been suggested that the IL-36 pathway plays an important role in innate immunity during psoriasis development, since mice overexpressing IL-36 along with deletion of IL-36Ra gene exhibited a severe psoriatic phenotype. We previously demonstrated that IL-36R KO completely abolished the development of psoriatic inflammation in K5.Stat3C mice.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research